ArticleJournal of cachexia, sarcopenia and muscle2010
The effects of a high-caloric protein-rich oral nutritional supplement in patients with chronic heart failure and cachexia on quality of life, body composition, and inflammation markers: a randomized, double-blind pilot study.
Article in Journal of cachexia, sarcopenia and muscle, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00654719 (The Influence of Enteral Nutrition on Functional Status and Inflammatory Activation in Patients With Congestive Heart Failure and Cardiac Cachexia.), which is not on this map. Cited by 78 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Enteral Nutrition on Functional Status and Inflammatory Activation in Patients With Congestive Heart Failure and Cardiac Cachexia.
Who cites it
78 citing papers in PubMed, 6 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- High-Protein Dietary Interventions in Heart Failure: A Systematic Review of Clinical and Functional Outcomes.Nutrients · 2025Pooled it
- Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Nutritional interventions for heart failure patients who are malnourished or at risk of malnutrition or cachexia: a systematic review and meta-analysis.Heart failure reviews · 2021Pooled it
- Nutrition in chronic heart failure patients: a systematic review.Heart failure reviews · 2020Pooled it
- The effect of protein and essential amino acid supplementation on muscle strength and performance in patients with chronic heart failure: a systematic review.European journal of nutrition · 2020Pooled it
- Nutritional Interventions in Heart Failure: A Systematic Review of the Literature.Journal of cardiac failure · 2015Pooled it
- SHORT-TERM EFFECT OF WHEY PROTEIN SUPPLEMENTATION ON THE QUALITY OF LIFE OF PATIENTS WAITING FOR LIVER TRANSPLANTATION: A DOUBLE BLINDED RANDOMIZED CLINICAL TRIAL.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2021Trial
- Sarcopenia in Chronic Heart Failure: Pathophysiology, Clinical Consequences, and Emerging Multimodal Therapeutic Strategies.Nutrients · 2026Review
- Mitochondrial cardiovascular diseases: molecular mechanisms, multi-omics exploration and therapeutic strategies.Journal of advanced research · 2026Review
- Effects of Enhanced Nutritional Care in Heart Failure - A Systematic Review and Meta-Analysis.Circulation reports · 2026Review
- Effects of Protein and Amino Acid Supplementation on Physical Performance in Patients With Chronic Heart Failure - A Systematic Review and Meta-Analysis.Circulation reports · 2026Review
- Association Between Refrigerator Openings and Protein Intake After Hospitalization for Heart Failure Decompensation: Protocol for a Prospective Cohort Pilot Study.JMIR research protocols · 2025Article
- Evaluation of potential mechanisms for skeletal muscle mass recovery early after left ventricular assist device implantation.JHLT open · 2025Article
- Sarcopenia in Ageing and Chronic Illness: Trial Endpoints and Regulatory Issues.Journal of cachexia, sarcopenia and muscle · 2025Article
- Navigating Sarcopenia Risks in GLP-1RA Therapy for Advanced Heart Failure.Biomedicines · 2025Review
- Extracellular fluid volume as a key indicator in home-care management of chronic heart failure: The role of nutritional and exercise therapy.Clinical case reports · 2024Article
- Relationship between cachexia and short physical performance battery scores in patients with heart failure attending comprehensive outpatient cardiac rehabilitation.Heart and vessels · 2024Article
- Oral nutritional supplements in older outpatients with heart failure: rationale and design of the ALIMENT-HF trial.ESC heart failure · 2024Article
- Prognostic value of geriatric nutritional risk index in patients with stable coronary artery disease undergoing percutaneous coronary intervention.BMC cardiovascular disorders · 2024Article
- Association between dietary inflammatory index and NT-proBNP levels in US adults: A cross-sectional analysis.PloS one · 2024Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of cardiac cachexia in chronic heart failure is approximately 5% to 15% and 18-month mortality rates can reach 50%. Treatment with angiotensin-converting enzyme inhibitors and beta-blockers may confer some benefit but no proven therapy exists. We tested the effects of an oral nutritional supplement in cachectic patients with heart failure. This was a prospective, randomized, double-blind, placebo-controlled pilot study which randomized 29 patients to a high-caloric (600 kcal) high-protein (20 g) oral nutritional supplement or placebo for a duration of 6 weeks in addition to the patients' usual food intake. At baseline, 6 weeks, and 18 weeks, we measured body weight, quality of life, body composition, heart function, laboratory parameters, and exercise performance. Edema-free body weight increased in 19 of 20 patients receiving intervention at 6 weeks and in 17 of 19 patients at 18 weeks with an average weight gain of 2.0 ± 1.7 kg (3.1 ± 2.4%, p = 0.0001) and 2.3 ± 3.1 kg (3.6 ± 4.7%, p = 0.007) at 6 and 18 weeks, respectively. Most of the weight gain was fat tissue with an absolute gain of 1.5 ± 1.7 kg (p = 0.003) and 1.6 ± 2.7 kg (p = 0.008). A significant improvement in quality of life and decrease in serum levels of tumor necrosis factor-α were observed (p < 0.05 for both). We demonstrated the feasibility of oral nutritional supplement in cachectic patients with heart failure and significant clinical benefit in terms of body size and body composition, laboratory parameters, and quality of life (www.clinicaltrials.gov identifier NCT00654719).
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.