ReviewNature reviews. Immunology2011
Design principles of adaptive immune systems.
Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- HuBIE: The human blood immunome encyclopedia of TCRs and BCRs in bloodstream infections and cancer.Frontiers in immunology · 2026Article
- Review
- Histocompatibility in Botryllus schlosseri and the origins of adaptive immunity.Immunogenetics · 2025Review
- Understanding vertebrate immunity through comparative immunology.Nature reviews. Immunology · 2025Review
- History of the Thymus: From a Vestigial Organ to the Programming of Immunological Self-Tolerance.Advances in experimental medicine and biology · 2025Review
- Review
- Efficacy of clove and tulsi supplementation in drinking water in broiler immunity.Veterinary medicine and science · 2023Article
- Long Non-Coding RNA Signatures in Lymphopoiesis and Lymphoid Malignancies.Non-coding RNA · 2023Review
- Immune repertoire profiling for disease pathobiology.Pathology international · 2023Review
- The mechanisms and cross-protection of trained innate immunity.Virology journal · 2022Review
- Review
- Review
- Linear B-Cell Epitope Prediction for In Silico Vaccine Design: A Performance Review of Methods Available via Command-Line Interface.International journal of molecular sciences · 2021Review
- The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system.Immunogenetics · 2021Review
- Evolution of thymopoietic microenvironments.Open biology · 2021Review
- Terminal deoxynucleotidyl transferase-mediated formation of protein binding polynucleotides.Nucleic acids research · 2021Article
- An in vivo screen of noncoding loci reveals thatProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Guardian of the Genome: An Alternative RAG/Transib Co-Evolution Hypothesis for the Origin of V(D)J Recombination.Frontiers in immunology · 2021Article
- A blueprint for translational regenerative medicine.Science translational medicine · 2020Review
- Retracing the evolutionary emergence of thymopoiesis.Science advances · 2020Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both jawless vertebrates, such as lampreys and hagfish, and jawed vertebrates (encompassing species as diverse as sharks and humans) have an adaptive immune system that is based on somatically diversified and clonally expressed antigen receptors. Although the molecular nature of the antigen receptors and the mechanisms of their assembly are different, recent findings suggest that the general design principles underlying the two adaptive immune systems are surprisingly similar. The identification of such commonalities promises to further our understanding of the mammalian immune system and to inspire the development of new strategies for medical interventions targeting the consequences of faulty immune functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.