ArticleMolecular & cellular proteomics : MCP2011
Label-free quantitative proteomics reveals differentially regulated proteins influencing urolithiasis.
Article in Molecular & cellular proteomics : MCP, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 41 citations in OpenAlex.
- Systematic proteomics analysis of lysine acetylation reveals critical features of renal proteins in kidney calculi formation.PloS one · 2026Article
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- Self-control study of multi-omics in identification of microenvironment characteristics in calcium oxalate kidney stones.BMC nephrology · 2025Article
- Anion exchange chromatographic fractionation of urinary proteins followed by tandem mass spectrometry identifies potential natural inhibitors of calcium oxalate stone.Computational and structural biotechnology journal · 2025Article
- Meta-data analysis of kidney stone disease highlights ATP1A1 involvement in renal crystal formation.Redox biology · 2023Article
- Protein network analysis and functional enrichment via computational biotechnology unravel molecular and pathogenic mechanisms of kidney stone disease.Biomedical journal · 2023Review
- iTRAQ-Based Comparative Proteomics Analysis of Urolithiasis Rats Induced by Ethylene Glycol.BioMed research international · 2020Article
- Urinary proteome in inherited nephrolithiasis.Urolithiasis · 2019Review
- A Proteomic Network Approach across the Kidney Stone Disease Reveals Endoplasmic Reticulum Stress and Crystal-Cell Interaction in the Kidney.Oxidative medicine and cellular longevity · 2019Article
- Stone former urine proteome demonstrates a cationic shift in protein distribution compared to normal.Urolithiasis · 2017Article
- Idiopathic hypercalciuria and formation of calcium renal stones.Nature reviews. Nephrology · 2016Review
- Assessment of Urine Proteomics in Type 1 Primary Hyperoxaluria.American journal of nephrology · 2016Article
- A quantitative proteomics analysis of MCF7 breast cancer stem and progenitor cell populations.Proteomics · 2015Article
- Urine proteomic analysis in cystinuric children with renal stones.Journal of pediatric urology · 2015Article
- Label-free quantitative urinary proteomics identifies the arginase pathway as a new player in congenital obstructive nephropathy.Molecular & cellular proteomics : MCP · 2014Article
- Phosphorylation stoichiometries of human eukaryotic initiation factors.International journal of molecular sciences · 2014Article
- Linkage of oxidative stress and mitochondrial dysfunctions to spontaneous culture degeneration in Aspergillus nidulans.Molecular & cellular proteomics : MCP · 2014Article
- Kidney stones: a fetal origins hypothesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Protein profiling in hepatocellular carcinoma by label-free quantitative proteomics in two west African populations.PloS one · 2013Article
- Novel mass spectrometric method for phosphorylation quantification using cerium oxide nanoparticles and tandem mass tags.Analytical chemistry · 2012Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Urinary proteins have been implicated as inhibitors of kidney stone formation (urolithiasis). As a proximal fluid, prefiltered by the kidneys, urine is an attractive biofluid for proteomic analysis in urologic conditions. However, it is necessary to correct for variations in urinary concentration. In our study, individual urine samples were normalized for this variation by using a total protein to creatinine ratio. Pooled urine samples were compared in two independent experiments. Differences between the urinary proteome of stone formers and nonstone-forming controls were characterized and quantified using label-free nano-ultraperformance liquid chromatography high/low collision energy switching analysis. There were 1063 proteins identified, of which 367 were unique to the stone former groups, 408 proteins were unique to the control pools, and 288 proteins were identified for comparative quantification. Proteins found to be unique in stone-formers were involved in carbohydrate metabolism pathways and associated with disease states. Thirty-four proteins demonstrated a consistent >twofold change between stone formers and controls. For ceruloplasmin, one of the proteins was shown to be more than twofold up-regulated in the stone-former pools, this observation was validated in individuals by enzyme-linked immunosorbent assay. Moreover, in vitro crystallization assays demonstrated ceruloplasmin had a dose-dependent increase on calcium oxalate crystal formation. Taken together, these results may suggest a functional role for ceruloplasmin in urolithiasis.
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