ArticleProceedings of the National Academy of Sciences of the United States of America2011
Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Engineering multifunctional surface topography to regulate multiple biological responses.Biomaterials · 2025Review
- Article
- Article
- Cell migration on microposts with surface coating and confinement.Bioscience reports · 2019Article
- Optimal Quantification of Contact Inhibition in Cell Populations.Biophysical journal · 2017Article
- Probing three-dimensional collective cancer invasion with DIGME.Cancer convergence · 2017Article
- Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells.Advanced materials interfaces · 2014Article
- Game theory in the death galaxy: interaction of cancer and stromal cells in tumour microenvironment.Interface focus · 2014Article
- Model on cell movement, growth, differentiation and de-differentiation: reaction-diffusion equation and wave propagation.The European physical journal. E, Soft matter · 2013Article
- Tumor cell migration in complex microenvironments.Cellular and molecular life sciences : CMLS · 2013Review
- Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation device.Lab on a chip · 2013Article
- Minimization of thermodynamic costs in cancer cell invasion.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Microfabricated arrays for splitting and assay of clonal colonies.Analytical chemistry · 2012Article
- Inter-cellular signaling network reveals a mechanistic transition in tumor microenvironment.Integrative biology : quantitative biosciences from nano to macro · 2012Article
- Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model.Cancer research · 2011Article
- Article
- Recapitulating cancer cell invasion in vitro.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Approaches to manipulating the dimensionality and physicochemical properties of common cellular scaffolds.International journal of molecular sciences · 2011Review
- Controlling matrix stiffness and topography for the study of tumor cell migration.Cell adhesion & migrationReview
Corrections and comments
- Commented on by
Authors and funding
7 authors.
Funding
Abstract
The metastatic invasion of cancer cells from primary tumors to distant ecological niches, rather than the primary tumors, is the cause of much cancer mortality [Zhang QB, et al. (2010) Int J Cancer 126:2534-2541; Chambers AF, Goss PE (2008) Breast Cancer Res 10:114]. Metastasis is a three-dimensional invasion process where cells spread from their site of origin and colonize distant microenvironmental niches. It is critical to be able to assess quantitatively the metastatic potential of cancer cells [Harma V, et al. (2010) PLoS ONE 5:e10431]. We have constructed a microfabricated chip with a three-dimensional topology consisting of lowlands and isolated square highlands (Tepuis), which stand hundreds of microns above the lowlands, in order to assess cancer cell metastatic potential as they invade the highlands. As a test case, the invasive ascents of the Tepui by highly metastatic PC-3 and noninvasive LNCaP prostate cancer cells were used. The vertical ascent by prostate cancer cells from the lowlands to the tops of the Tepui was imaged using confocal microscopy and used as a measure of the relative invasiveness. The less-metastatic cells (LNCaP) never populated all available tops, leaving about 15% of them unoccupied, whereas the more metastatic PC-3 cells occupied all available Tepuis. We argue that this distinct difference in invasiveness is due to contact inhibition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.