ArticleInvestigative ophthalmology & visual science2011
Variation in rhodopsin kinase expression alters the dim flash response shut off and the light adaptation in rod photoreceptors.
Article in Investigative ophthalmology & visual science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The effects of bicarbonate on the aberrant photon response in murine rod photoreceptors.Biophysical journal · 2026Article
- Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.Frontiers in molecular neuroscience · 2022Article
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Phosphorylation at Serine 21 in G protein-coupled receptor kinase 1 (GRK1) is required for normal kinetics of dark adaption in rod but not cone photoreceptors.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- A quantitative account of mammalian rod phototransduction with PDE6 dimeric activation: responses to bright flashes.Open biology · 2020Article
- The Binding Properties and Physiological Functions of Recoverin.Frontiers in molecular neuroscience · 2018Review
- Slow light response kinetics in rods points towards a perturbation of the normal cellular milieu.The Journal of physiology · 2015Article
- Regulation of mammalian cone phototransduction by recoverin and rhodopsin kinase.The Journal of biological chemistry · 2015Article
- Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.The Journal of general physiology · 2015Article
- Protein and Signaling Networks in Vertebrate Photoreceptor Cells.Frontiers in molecular neuroscience · 2015Review
- Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling.Cell communication and signaling : CCS · 2013Article
- Modulation of mouse rod response decay by rhodopsin kinase and recoverin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeRod photoreceptors are exquisitely sensitive light detectors that function in dim light. The timely inactivation of their light responses is critical for the ability of rods to reliably detect and count photons. A key step in the inactivation of the rod transduction is the phosphorylation of the rod visual pigment, rhodopsin, catalyzed by G-protein-dependent receptor kinase 1 (GRK1). Absence of GRK1 greatly prolongs the photoreceptors' light response and enhances their susceptibility to degeneration. This study examined the light responses from mouse rods expressing various levels of GRK1 to evaluate how their function is modulated by rhodopsin inactivation.
methodsTransretinal and single-cell rod electrophysiological recordings were obtained from several strains of mice expressing GRK1 at 0.3- to 3-fold the wild-type levels. The effect of GRK1 expression level on the function of mouse rods was examined in darkness and during background adaptation.
resultsAltering the expression of GRK1 from 0.3- to 3-fold that in wild-type rods had little effect on the single photon response amplitude. Notably, increasing the expression level of GRK1 accelerated the dim flash response shut off but had no effect on the saturated response shut off. Additionally, GRK1 excess abolished the acceleration of saturated responses shut off during light adaptation.
conclusionsThese results demonstrate that rhodopsin inactivation can modulate the kinetics of recovery from dim light stimulation. More importantly, the ratio of rhodopsin kinase to its modulator recoverin appears critical for the proper adaptation of rods and the acceleration of their response shut off in background light.
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