ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Convective flow dominates aerosol delivery to the lung segments.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Measuring Anatomical Distributions of Ventilation and Aerosol Deposition with PET-CT.Journal of aerosol medicine and pulmonary drug delivery · 2023Review
- Measuring short-term changes in specific ventilation using dynamic specific ventilation imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Aerosol Transport Modeling: The Key Link Between Lung Infections of Individuals and Populations.Frontiers in physiology · 2022Review
- In silico optimization of targeted aerosol delivery in upper airways via Inhaled Volume Tracking.Clinical biomechanics (Bristol, Avon) · 2020Article
- Regional airflow obstruction after bronchoconstriction and subsequent bronchodilation in subjects without pulmonary disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.Respirology (Carlton, Vic.) · 2019Article
- Airway morphology and inspiratory flow features in the early stages of Chronic Obstructive Pulmonary Disease.Clinical biomechanics (Bristol, Avon) · 2019Article
- Regional Ventilation Is the Main Determinant of Alveolar Deposition of Coarse Particles in the Supine Healthy Human Lung During Tidal Breathing.Journal of aerosol medicine and pulmonary drug delivery · 2017Article
- INHALED AEROSOL DOSIMETRY: SOME CURRENT RESEARCH NEEDS.Journal of aerosol science · 2016Article
- Regional Ventilation and Aerosol Deposition with Helium-Oxygen in Bronchoconstricted Asthmatic Lungs.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung.Journal of aerosol medicine and pulmonary drug delivery · 2016Review
- What Causes Uneven Aerosol Deposition in the Bronchoconstricted Lung? A Quantitative Imaging Study.Journal of aerosol medicine and pulmonary drug delivery · 2016Article
- The Creation and Statistical Evaluation of a Deterministic Model of the Human Bronchial Tree from HRCT Images.PloS one · 2016Article
- Computational modeling of the obstructive lung diseases asthma and COPD.Journal of translational medicine · 2014Article
- Airflow and particle deposition simulations in health and emphysema: from in vivo to in silico animal experiments.Annals of biomedical engineering · 2014Article
- Early airway structural changes in cystic fibrosis pigs as a determinant of particle distribution and deposition.Annals of biomedical engineering · 2014Article
- Regional distribution of aerosol deposition in rat lungs using magnetic resonance imaging.Annals of biomedical engineering · 2013Article
- Effect of carrier gas properties on aerosol distribution in a CT-based human airway numerical model.Annals of biomedical engineering · 2012Article
- Aerosol deposition in health and disease.Journal of aerosol medicine and pulmonary drug delivery · 2012Review
- Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Most previous computational studies on aerosol transport in models of the central airways of the human lung have focused on deposition, rather than transport of particles through these airways to the subtended lung regions. Using a model of the bronchial tree extending from the trachea to the segmental bronchi (J Appl Physiol 98: 970-980, 2005), we predicted aerosol delivery to the lung segments. Transport of 0.5- to 10-μm-diameter particles was computed at various gravity levels (0-1.6 G) during steady inspiration (100-500 ml/s). For each condition, the normalized aerosol distribution among the lung segments was compared with the normalized flow distribution by calculating the ratio (R(i)) of the number of particles exiting each segmental bronchus i to the flow. When R(i) = 1, particle transport was directly proportional to segmental flow. Flow and particle characteristics were represented by the Stokes number (Stk) in the trachea. For Stk < 0.01, R(i) values were close to 1 and were unaffected by gravity. For Stk > 0.01, R(i) varied greatly among the different outlets (R(i) = 0.30-1.93 in normal gravity for 10-μm particles at 500 ml/s) and was affected by gravity and inertia. These data suggest that, for Stk < 0.01, ventilation defines the delivery of aerosol to lung segments and that the use of aerosol tracers is a valid technique to visualize ventilation in different parts of the lung. At higher Stokes numbers, inertia, but not gravitational sedimentation, is the second major factor affecting the transport of large particles in the lung.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.