Evidence map›Paper›PMID 21474660›Full record

ReviewAnesthesia and analgesia2011

Review articles: postoperative delirium: acute change with long-term implications.

James L Rudolph, Edward R Marcantonio

3 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Anesthesia and analgesia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 242 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
242citing papers in PubMed, 11 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04093219 phase3completednot on this mapstarted 2020, after this paper: background citation

PANDORA: Scheduled Prophylactic 6-hourly Intravenous Acetaminophen to Prevent Postoperative Delirium in Older Cardiac Surgical Patients

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2020 to 2026Enrolled900ConditionsDelirium in Old Age, Delirium, Coronary Artery DiseaseArmsIV acetaminophen, Placebo
NCT04643834 completednot on this mapstarted 2019, after this paper: background citation

Validation of Cerebral Non-invasive Monitoring and Prediction of Post-operative Delirium and Outcomes: A Prospective Observational Study

TypeobservationalSponsorMontreal Heart InstituteRan2019 to 2023Enrolled153ConditionsDelirium, Cerebral Desaturation, EEG With Abnormally Slow Frequencies
NCT06817239 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Perioperative Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Major Non-cardiac Surgery: a Multi-center Randomized Trial (ELEMENT Trial)

TypeinterventionalSponsorNanfang Hospital, Southern Medical UniversityRan2025 to 2027Enrolled1,670ConditionsDelirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive DysfunctionArmsEsketamine, Normal saline
3 · Its place in the literature

Who cites it

242 citing papers in PubMed, 11 syntheses or guidelines pooled it, 595 citations in OpenAlex.

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  11. Antipsychotics for treatment of delirium in hospitalised non-ICU patients.The Cochrane database of systematic reviews · 2018
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182 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

James L RudolphGeriatric Research, Education, and Clinical Center, VA Boston Healthcare System GRECC, 150 South Huntington Ave., Boston, MA 02130, USA. jrudolph@partners.org
Edward R Marcantonio
Brigham and Women's Hospital · USHarvard University · US

Funding

Mid-Career Mentoring Award for Patient-Oriented Research in AgingK24AG035075 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MARCANTONIO, EDWARD R · 2010 to 2021
$1.9M
NIA NIH HHS K24 AG035075
6 · The paper itself

Abstract

Delirium is an acute change in cognition and attention, which may include alterations in consciousness and disorganized thinking. Although delirium may affect any age group, it is most common in older patients, especially those with preexisting cognitive impairment. Patients with delirium after surgery recover more slowly than those without delirium and, as a result, have increased length of stay and hospital costs. The measured incidence of postoperative delirium varies with the type of surgery, the urgency of surgery, and the type and sensitivity of the delirium assessment. Although generally considered a short-term condition, delirium can persist for months and is associated with poor cognitive and functional outcomes beyond the immediate postoperative period. In this article, we provide a guide to assess delirium risk preoperatively and to prevent, diagnose, and treat this common and morbid condition. Care improvements such as identifying delirium risk preoperatively; training surgeons, anesthesiologists, and nurses to screen for delirium; implementing delirium prevention programs; and developing standardized delirium treatment protocols may reduce the risk of delirium and its associated morbidity.

Indexed as

Age FactorsAttentionCognitionCognition DisordersComorbidityDeliriumDepressionHumansRisk AssessmentRisk FactorsSurgical Procedures, OperativeTime FactorsTreatment Outcome

Identifiers

PMID21474660
PMCPMC3090222
OpenAlexW2105995566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.