ArticleBiosensors & bioelectronics2011
Analysis of inflammatory biomarkers by Arrayed Imaging Reflectometry.
Article in Biosensors & bioelectronics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Two Decades of Arrayed Imaging Reflectometry for Sensitive, High-Throughput Biosensing.Biosensors · 2023Review
- Immunosensor-based label-free and multiplex detection of influenza viruses: State of the art.Biosensors & bioelectronics · 2019Review
- Crowd on a Chip: Label-Free Human Monoclonal Antibody Arrays for Serotyping Influenza.Analytical chemistry · 2018Article
- Functionalized Polymer Microgel Particles Enable Customizable Production of Label-Free Sensor Arrays.Analytical chemistry · 2015Article
- Discrimination of "specific" and "nonspecific" binding in two-dimensional photonic crystals.Optics express · 2015Article
- Bioanalytical chemistry of cytokines--a review.Analytica chimica acta · 2015Review
- Examining the interactions of the splicing factor MBNL1 with target RNA sequences via a label-free, multiplex method.Analytical chemistry · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Levels of serum cytokines are important markers for a broad range of human health conditions, ranging from infectious disease and cancer, to pollutant exposure and stress. In the interest of developing new rapid label-free methods for profiling serum cytokines, we have examined the utility of Arrayed Imaging Reflectometry (AIR) microarrays for this application. We find that AIR is readily able to profile 14 cytokines and other inflammatory biomarker proteins in a background of buffered bovine serum albumin or 1% bovine serum with performance metrics comparable to singleplex ELISA, but in a multiplex, chip-based, reagentless format. Further experiments with interferon-gamma (IFN-γ) demonstrated that the concentration of bovine serum could be increased to at least 20% without changing the overall analytical profile or limit of detection (<10 pg/mL).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.