ArticleVirus research2011
Vascular endothelial growth factor (VEGF), produced by feline infectious peritonitis (FIP) virus-infected monocytes and macrophages, induces vascular permeability and effusion in cats with FIP.
Article in Virus research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 36 citations in OpenAlex.
- Thoracic radiographic findings in cats with feline infectious peritonitis.Journal of feline medicine and surgery · 2025Article
- Phylogenetic, clinical, pathological and epidemiological characterization of feline coronavirus infections in cats, in Istanbul.Frontiers in veterinary science · 2025Article
- Article
- Relationship between Uveal Inflammation and Viral Detection in 30 Cats with Feline Infectious Peritonitis.Pathogens (Basel, Switzerland) · 2022Article
- Role of Feline Coronavirus as Contributor to Diarrhea in Cats from Breeding Catteries.Viruses · 2022Article
- Evolution, Interspecies Transmission, and Zoonotic Significance of Animal Coronaviruses.Frontiers in veterinary science · 2021Review
- Colony Stimulating Factors in Early Feline Infectious Peritonitis Virus Infection of Monocytes and in End Stage Feline Infectious Peritonitis; A Combined In Vivo And In Vitro Approach.Pathogens (Basel, Switzerland) · 2020Article
- Coronavirus Infections in Companion Animals: Virology, Epidemiology, Clinical and Pathologic Features.Viruses · 2020Review
- Article
- Therapeutic effect of an anti-human-TNF-alpha antibody and itraconazole on feline infectious peritonitis.Archives of virology · 2020Article
- Endocytic Pathway of Feline Coronavirus for Cell Entry: Differences in Serotype-Dependent Viral Entry Pathway.Pathogens (Basel, Switzerland) · 2019Article
- Feline Infectious Peritonitis as a Systemic Inflammatory Disease: Contribution of Liver and Heart to the Pathogenesis.Viruses · 2019Article
- Article
- Inflammatory Mediators in the Mesenteric Lymph Nodes, Site of a Possible Intermediate Phase in the Immune Response to Feline Coronavirus and the Pathogenesis of Feline Infectious Peritonitis?Journal of comparative pathology · 2019Article
- Genome-wide analysis of differentially expressed genes and the modulation of PEDV infection in Vero E6 cells.Microbial pathogenesis · 2018Article
- Expression profiles of immune mediators in feline Coronavirus-infected cells and clinical samples of feline Coronavirus-positive cats.BMC veterinary research · 2017Article
- Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis.Research in veterinary science · 2016Article
- Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis.Advances in virus research · 2016Review
- Apoptosis transcriptional mechanism of feline infectious peritonitis virus infected cells.Apoptosis : an international journal on programmed cell death · 2015Article
- An update on feline infectious peritonitis: virology and immunopathogenesis.Veterinary journal (London, England : 1997) · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feline infectious peritonitis virus (FIPV) causes a fatal disease called FIP in Felidae. The effusion in body cavity is commonly associated with FIP. However, the exact mechanism of accumulation of effusion remains unclear. We investigated vascular endothelial growth factor (VEGF) to examine the relationship between VEGF levels and the amounts of effusion in cats with FIP. Furthermore, we examined VEGF production in FIPV-infected monocytes/macrophages, and we used feline vascular endothelial cells to examine vascular permeability induced by the culture supernatant of FIPV-infected macrophages. In cats with FIP, the production of effusion was related with increasing plasma VEGF levels. In FIPV-infected monocytes/macrophages, the production of VEGF was associated with proliferation of virus. Furthermore, the culture supernatant of FIPV-infected macrophages induced hyperpermeability of feline vascular endothelial cells. It was suggested that vascular permeability factors, including VEGF, produced by FIPV-infected monocytes/macrophages might increase the vascular permeability and the amounts of effusion in cats with FIP.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.