ArticleJournal of the International Society of Sports Nutrition2011
No effect of short-term amino acid supplementation on variables related to skeletal muscle damage in 100 km ultra-runners - a randomized controlled trial.
Article in Journal of the International Society of Sports Nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Protein Nutrition for Endurance Athletes: A Metabolic Focus on Promoting Recovery and Training Adaptation.Sports medicine (Auckland, N.Z.) · 2025Review
- Decoding Ultramarathon: Muscle Damage as the Main Impediment to Performance.Sports medicine (Auckland, N.Z.) · 2025Review
- Association of Genetically Predicted BCAA Levels with Muscle Fiber Size in Athletes Consuming Protein.Genes · 2022Article
- The Consequences of Training and Competition to the Musculoskeletal System in Ultramarathon Runners: A Narrative Review.Frontiers in physiology · 2021Review
- International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing.Journal of the International Society of Sports Nutrition · 2019Review
- Nutrition in Ultra-Endurance: State of the Art.Nutrients · 2018Review
- Physiology and Pathophysiology in Ultra-Marathon Running.Frontiers in physiology · 2018Review
- Nutritional implications for ultra-endurance walking and running events.Extreme physiology & medicine · 2016Review
- Changes in Serum Free Amino Acids and Muscle Fatigue Experienced during a Half-Ironman Triathlon.PloS one · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to investigate the effect of short-term supplementation of amino acids before and during a 100 km ultra-marathon on variables of skeletal muscle damage and muscle soreness. We hypothesized that the supplementation of amino acids before and during an ultra-marathon would lead to a reduction in the variables of skeletal muscle damage, a decrease in muscle soreness and an improved performance.
methodsTwenty-eight experienced male ultra-runners were divided into two groups, one with amino acid supplementation and the other as a control group. The amino acid group was supplemented a total of 52.5 g of an amino acid concentrate before and during the 100 km ultra-marathon. Pre- and post-race, creatine kinase, urea and myoglobin were determined. At the same time, the athletes were asked for subjective feelings of muscle soreness.
resultsRace time was not different between the groups when controlled for personal best time in a 100 km ultra-marathon. The increases in creatine kinase, urea and myoglobin were not different in both groups. Subjective feelings of skeletal muscle soreness were not different between the groups.
conclusionsWe concluded that short-term supplementation of amino acids before and during a 100 km ultra-marathon had no effect on variables of skeletal muscle damage and muscle soreness.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.