ReviewExpert opinion on drug metabolism & toxicology2011
The effect of therapeutic hypothermia on drug metabolism and response: cellular mechanisms to organ function.
Review in Expert opinion on drug metabolism & toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 97 citations in OpenAlex.
- Pharmacokinetics of morphine in encephalopathic neonates treated with therapeutic hypothermia.PloS one · 2019Trial
- Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury.Critical care medicine · 2013Trial
- Development and validation of a predictive model for delayed emergence from anesthesia in elderly patients undergoing video-assisted thoracoscopic surgery: a retrospective study.BMC anesthesiology · 2026Article
- Accidental hypothermia.Nature reviews. Disease primers · 2026Review
- Management of Hypoxemic Respiratory Failure in the Newborn During Therapeutic Hypothermia.Clinics in perinatology · 2026Review
- Impact of environmentally induced hypothermia on fentanyl and norfentanyl pharmacokinetics following intravenous administration to Wistar rats.Pharmacological reports : PR · 2026Article
- Review
- Impact of Hypothermic Temperature Control on Plasma and Soft Tissue Pharmacokinetics of Penicillin/Beta-Lactamase Inhibitor Combinations in Patients Resuscitated After Cardiac Arrest.Clinical pharmacokinetics · 2025Article
- Pharmacotherapy variability and precision medicine in neurocritical care.Frontiers in neurology · 2025Review
- Combined endovascular interventions for pulmonary embolism at high altitude in Tibet.Frontiers in cardiovascular medicine · 2024Article
- Potential pharmacological confounders in the setting of death determined by neurologic criteria: a narrative review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2023Review
- Super-Refractory Status Epilepticus: Prognosis and Recent Advances in Management.Aging and disease · 2021Review
- Current State of Analgesia and Sedation in the Pediatric Intensive Care Unit.Journal of clinical medicine · 2021Review
- Effect of intravenous fluid warming on core body temperature during elective orthopedic procedures.The Canadian veterinary journal = La revue veterinaire canadienne · 2020Article
- The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep.International journal of molecular sciences · 2020Article
- State-of-the-art considerations in post-arrest care.Journal of the American College of Emergency Physicians open · 2020Review
- A Comprehensive Update of Current Anesthesia Perspectives on Therapeutic Hypothermia.Advances in therapy · 2019Review
- What is the predictor of the intraoperative body temperature in abdominal surgery?Journal of anesthesia · 2019Article
- Visceral fat, but not subcutaneous fat, is associated with lower core temperature during laparoscopic surgery.PloS one · 2019Article
- Drug Disposition and Pharmacotherapy in Neonatal ECMO: From Fragmented Data to Integrated Knowledge.Frontiers in pediatrics · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
introductionTherapeutic hypothermia is being employed clinically due to its neuro-protective benefits. Both critical illness and therapeutic hypothermia significantly affect drug disposition, potentially contributing to drug-therapy and drug-disease interactions. Currently, there is limited information on the known alterations in drug concentration and response during mild hypothermia treatment, and there is a limited understanding of the specific mechanisms that underlie alterations in drug concentrations and the potential clinical importance of these changes. AREAS COVERED: A systemic review of the effect of therapeutic hypothermia on drug metabolism, disposition and response is provided. Specifically, the clinical and preclinical evidence of the effects of therapeutic hypothermia on blood flow, specific hepatic metabolism pathways, transporter function, renal excretion, pharmacodynamics and the effects during rewarming are reviewed. EXPERT OPINION: Available evidence demonstrates that mild hypothermia decreases the clearance of a variety of drugs with apparently little change in drug-protein binding. Recent evidence suggests that the magnitude of the change is elimination route specific. Further research is needed to determine the impact of these alterations on both drug concentration and response in order to optimize the therapeutic hypothermia in this vulnerable patient population.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.