ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2011
Visual threshold is set by linear and nonlinear mechanisms in the retina that mitigate noise: how neural circuits in the retina improve the signal-to-noise ratio of the single-photon response.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Selective knockout of murine glutamic acid-rich protein 2 significantly alters dark continuous noise in rod photoreceptors.The Journal of physiology · 2026Article
- The Hidden Benefits of Noise: Low-Frequency tRNS and Dynamic Visual Noise Enhance Visual Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Photoreceptor-Like Signal Transduction Between Polymer-Based Protocells.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Regional variation in the organization and connectivity of the first synapse in the primate night vision pathway.iScience · 2023Article
- Article
- Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations.Pharmaceutics · 2022Review
- Flexible Neural Network Realized by the Probabilistic SiOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Review
- Evolutionary adaptation of visual pigments in geckos for their photic environment.Science advances · 2021Article
- Transmission at rod and cone ribbon synapses in the retina.Pflugers Archiv : European journal of physiology · 2021Review
- Rhodopsin: A Potential Biomarker for Neurodegenerative Diseases.Frontiers in neuroscience · 2020Review
- Large-Scale Convergence of Receptor Cell Arrays Onto Afferent Terminal Arbors in the Lorenzinian Electroreceptors ofFrontiers in neuroanatomy · 2020Article
- Reproductive State Modulates Retinal Sensitivity to Light in Female Túngara Frogs.Frontiers in behavioral neuroscience · 2019Article
- Waveband specific transcriptional control of select genetic pathways in vertebrate skin (Xiphophorus maculatus).BMC genomics · 2018Article
- Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates.Communications biology · 2018Article
- Ex Vivo Functional Evaluation of Synaptic Transmission from Rods to Rod Bipolar Cells in Mice.Methods in molecular biology (Clifton, N.J.) · 2018Article
- The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.Annual review of vision science · 2017Review
- Elevated cAMP improves signal-to-noise ratio in amphibian rod photoreceptors.The Journal of general physiology · 2017Article
- Adaptation of cone pigments found in green rods for scotopic vision through a single amino acid mutation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In sensory biology, a major outstanding question is how sensory receptor cells minimize noise while maximizing signal to set the detection threshold. This optimization could be problematic because the origin of both the signals and the limiting noise in most sensory systems is believed to lie in stimulus transduction. Signal processing in receptor cells can improve the signal-to-noise ratio. However, neural circuits can further optimize the detection threshold by pooling signals from sensory receptor cells and processing them using a combination of linear and nonlinear filtering mechanisms. In the visual system, noise limiting light detection has been assumed to arise from stimulus transduction in rod photoreceptors. In this context, the evolutionary optimization of the signal-to-noise ratio in the retina has proven critical in allowing visual sensitivity to approach the limits set by the quantal nature of light. Here, we discuss how noise in the mammalian retina is mitigated to allow for highly sensitive night vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.