ArticleJournal of the American Society for Mass Spectrometry2011
Differentiation of regioisomeric aromatic ketocarboxylic acids by positive mode atmospheric pressure chemical ionization collision-activated dissociation tandem mass spectrometry in a linear quadrupole ion trap mass spectrometer.
Article in Journal of the American Society for Mass Spectrometry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Studying the Intrinsic Reactivity of Chromanes by Gas-Phase Infrared Spectroscopy.Journal of the American Society for Mass Spectrometry · 2024Article
- Identification of Carboxylate, Phosphate, and Phenoxide Functionalities in Deprotonated Molecules Related to Drug Metabolites via Ion-Molecule Reactions with water and Diethylhydroxyborane.Journal of the American Society for Mass Spectrometry · 2017Article
- Fragmentation of Protonated N-(3-Aminophenyl)Benzamide and Its Derivatives in Gas Phase.Journal of the American Society for Mass Spectrometry · 2016Article
- "Meta elimination," a diagnostic fragmentation in mass spectrometry.Journal of the American Society for Mass Spectrometry · 2011Article
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Authors and funding
8 authors.
Funding
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Abstract
Positive-mode atmospheric pressure chemical ionization tandem mass spectrometry (APCI-MS(n)) was tested for the differentiation of regioisomeric aromatic ketocarboxylic acids. Each analyte forms exclusively an abundant protonated molecule upon ionization via positive-mode APCI in a commercial linear quadrupole ion trap (LQIT) mass spectrometer. Energy-resolved collision-activated dissociation (CAD) experiments carried out on the protonated analytes revealed fragmentation patterns that varied based on the location of the functional groups. Unambiguous differentiation between the regioisomers was achieved in each case by observing different fragmentation patterns, different relative abundances of ion-molecule reaction products, or different relative abundances of fragment ions formed at different collision energies. The mechanisms of some of the reactions were examined by H/D exchange reactions and molecular orbital calculations.
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