Evidence map›Paper›PMID 21472551›Full record

ArticleJournal of the American Society for Mass Spectrometry2011

An external matrix-assisted laser desorption ionization source for flexible FT-ICR Mass spectrometry imaging with internal calibration on adjacent samples.

Donald F Smith, Konstantin Aizikov, Marc C Duursma, Frans Giskes, Dirk-Jan Spaanderman, Liam A McDonnell, Peter B O'Connor, Ron M A Heeren

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Advanced mass calibration and visualization for FT-ICR mass spectrometry imaging.Journal of the American Society for Mass Spectrometry · 2012
    Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Donald F SmithFOM Institute for Atomic and Molecular Physics, Science Park 104, 1098 XG Amsterdam, The Netherlands.
Konstantin Aizikov
Marc C Duursma
Frans Giskes
Dirk-Jan Spaanderman
Liam A McDonnell
Peter B O'Connor
Ron M A Heeren

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe the construction and application of a new MALDI source for FT-ICR mass spectrometry imaging. The source includes a translational X-Y positioning stage with a 10×10 cm range of motion for analysis of large sample areas, a quadrupole for mass selection, and an external octopole ion trap with electrodes for the application of an axial potential gradient for controlled ion ejection. An off-line LC MALDI MS/MS run demonstrates the utility of the new source for data- and position-dependent experiments. A FT-ICR MS imaging experiment of a coronal rat brain section yields ∼200 unique peaks from m/z 400-1100 with corresponding mass-selected images. Mass spectra from every pixel are internally calibrated with respect to polymer calibrants collected from an adjacent slide.

Indexed as

AnimalsBacterial ProteinsBrain ChemistryCalibrationFourier AnalysisHistocytochemistryLipidsMolecular ImagingRatsSerine EndopeptidasesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationBacterial ProteinsLipidsmicrobial serine proteinasesSerine Endopeptidases

Identifiers

PMID21472551
PMCPMC3042104

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.