ArticleMolecular and cellular biology1990
Regulation of N-myc gene expression: use of an adenovirus vector to demonstrate posttranscriptional control.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Cooperative action of multiple cis-acting elements is required for N-myc expression in branchial arches: specific contribution of GATA3.Molecular and cellular biology · 2010Article
- Article
- A novel intron element operates posttranscriptionally To regulate human N-myc expression.Molecular and cellular biology · 1999Article
- MYC abrogates p53-mediated cell cycle arrest in N-(phosphonacetyl)-L-aspartate-treated cells, permitting CAD gene amplification.Molecular and cellular biology · 1998Article
- Quail Pax-6 (Pax-QNR) mRNAs are expressed from two promoters used differentially during retina development and neuronal differentiation.Molecular and cellular biology · 1995Article
- Identification and characterization of a neuroretina-specific enhancer element in the quail Pax-6 (Pax-QNR) gene.Molecular and cellular biology · 1995Article
- Strong conservation of non-coding sequences during vertebrates evolution: potential involvement in post-transcriptional regulation of gene expression.Nucleic acids research · 1993Article
- Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses.Molecular and cellular biology · 1993Article
- Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter.Molecular and cellular biology · 1992Article
- Hepadnavirus integration: mechanisms of activation of the N-myc2 retrotransposon in woodchuck liver tumors.Journal of virology · 1992Article
- Transcriptional down-regulation of N-myc expression during B-cell development.Molecular and cellular biology · 1992Article
- Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.Molecular and cellular biology · 1991Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
We present evidence that differences in the levels of N-myc mRNA among different cell types are the result of posttranscriptional control. First, we noted that while steady-state mouse N-myc mRNA could be detected only in fetal mouse brain, it was transcribed at an equivalent rate in adult brain, liver, spleen, and placenta and in fetal brain. Similarly, the human N-myc gene was transcribed at an equivalent rate in HeLa cells, which do not accumulate this RNA in the cytoplasm, and cell lines G401 (a Wilms tumor-derived cell line) and SKNMc (established from a primitive neuroepithelioma), which do express N-myc RNA. As expected, the N-myc promoter functioned at equivalent rates, as demonstrated by the level of a reporter gene, when introduced into these cell types by using a recombinant adenovirus vector. The suggestion that posttranscriptional mechanisms control the level of this RNA was supported by the observation that sequences in the N-myc third exon specifically decreased the level of E1A mRNA when these sequences were placed downstream of the E1A promoter in a recombinant adenovirus. Finally, we further localized these sequences to a 600-bp fragment of the third exon by introducing various subclones of this sequence downstream of the E1A promoter in both viral and plasmid vectors.
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