ArticleWorld journal of gastroenterology2011
Omeprazole decreases magnesium transport across Caco-2 monolayers.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Current opinion on the regulation of small intestinal magnesium absorption.World journal of gastroenterology · 2023Review
- Mechanisms of proton pump inhibitor-induced hypomagnesemia.Acta physiologica (Oxford, England) · 2022Review
- Evaluation of mutagenesis, necrosis and apoptosis induced by omeprazole in stomach cells of patients with gastritis.Cancer cell international · 2022Article
- Is there a correlation between hypomagnesemia linked to long-term proton pump inhibitor use and the active agent?Wiener klinische Wochenschrift · 2022Article
- A New Caco-2 Cell Model of in Vitro Intestinal Barrier: Application for the Evaluation of Magnesium Salts Absorption.Physiological research · 2021Article
- Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes.ACS omega · 2021Article
- Do medicines commonly used by older adults impact their nutrient status?Exploratory research in clinical and social pharmacy · 2021Review
- Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium.Molecules (Basel, Switzerland) · 2021Article
- Ultrastructural intestinal mucosa change after prolonged inhibition of gastric acid secretion by omeprazole in male rats.Anatomical science international · 2021Article
- The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes.Molecules (Basel, Switzerland) · 2020Review
- Effect of prolonged omeprazole administration on segmental intestinal MgWorld journal of gastroenterology · 2020Article
- The inhibitory role of purinergic P2Y receptor on MgThe journal of physiological sciences : JPS · 2019Article
- Challenges in the Diagnosis of Magnesium Status.Nutrients · 2018Review
- Bioaccessibility and Bioavailability of a Marine-Derived Multimineral, Aquamin-Magnesium.Nutrients · 2018Article
- The role of magnesium sulfate in the intensive care unit.EXCLI journal · 2017Review
- Omeprazole suppressed plasma magnesium level and duodenal magnesium absorption in male Sprague-Dawley rats.Pflugers Archiv : European journal of physiology · 2016Article
- The relationship between proton pump inhibitor use and serum magnesium concentration among hemodialysis patients: a cross-sectional study.BMC nephrology · 2015Article
- Dietary Inulin Fibers Prevent Proton-Pump Inhibitor (PPI)-Induced Hypocalcemia in Mice.PloS one · 2015Article
- Proton-pump inhibitor use is associated with lower urinary magnesium excretion.Nephrology (Carlton, Vic.) · 2014Article
- Hypomagnesemia in the intensive care unit: Choosing your gastrointestinal prophylaxis, a case report and review of the literature.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo elucidate the effect and underlying mechanisms of omeprazole action on Mg(2+) transport across the intestinal epithelium.
methodsCaco-2 monolayers were cultured in various dose omeprazole-containing media for 14 or 21 d before being inserted into a modified Ussing chamber apparatus to investigate the bi-directional Mg(2+) transport and electrical parameters. Paracellular permeability of the monolayer was also observed by the dilution potential technique and a cation permeability study. An Arrhenius plot was performed to elucidate the activation energy of passive Mg(2+) transport across the Caco-2 monolayers.
resultsBoth apical to basolateral and basolateral to apical passive Mg(2+) fluxes of omeprazole-treated epithelium were decreased in a dose- and time-dependent manner. Omeprazole also decreased the paracellular cation selectivity and changed the paracellular selective permeability profile of Caco-2 epithelium to Li(+), Na(+), K(+), Rb(+), and Cs(+) from series VII to series VI of the Eisenman sequence. The Arrhenius plot revealed the higher activation energy for passive Mg(2+) transport in omeprazole-treated epithelium than that of control epithelium, indicating that omeprazole affected the paracellular channel of Caco-2 epithelium in such a way that Mg(2+) movement was impeded.
conclusionOmeprazole decreased paracellular cation permeability and increased the activation energy for passive Mg(2+) transport of Caco-2 monolayers that led to the suppression of passive Mg(2+) absorption.
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