ReviewWorld journal of gastroenterology2011
Pathogenesis of occult chronic hepatitis B virus infection.
Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- [Current status of research on the impairment of natural killer cell function caused by hepatitis B virus infection].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025Review
- Prevalence of hepatitis B virus core antibodies among blood donors in Nigeria: Implications for blood safety.African journal of laboratory medicine · 2022Article
- Effectiveness of PCR primers for the detection of occult hepatitis B virus infection in Mexican patients.PloS one · 2018Article
- Characterization of hepatitis B virus in Amerindian children and mothers from Amazonas State, Colombia.PloS one · 2017Article
- Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA.Hepatitis monthly · 2016Article
- Occult Hepatitis B virus infection in previously screened, blood donors in Ile-Ife, Nigeria: implications for blood transfusion and stem cell transplantation.Virology journal · 2016Article
- Occult hepatitis B virus infection: clearance or disguise?Clinical and molecular hepatology · 2014Article
- Occult hepatitis B virus and hepatocellular carcinoma.World journal of gastroenterology · 2014Review
- Potential mutations associated with occult hepatitis B virus status.Hepatitis monthly · 2014Review
- Review
- Occult hepatitis B: clinical viewpoint and management.Hepatitis research and treatment · 2013Article
- Repeated exposure to trace amounts of woodchuck hepadnavirus induces molecularly evident infection and virus-specific T cell response in the absence of serological infection markers and hepatitis.Journal of virology · 2013Article
- Occult hepatitis B virus infection: a complex entity with relevant clinical implications.World journal of gastroenterology · 2011Article
- The Prevalence of Occult Hepatitis B Infection among Blood Donors in Lagos, Nigeria.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Occult hepatitis B infection (OBI) is characterized by hepatitis B virus (HBV) DNA in serum in the absence of hepatitis B surface antigen (HBsAg) presenting HBsAg-negative and anti-HBc positive serological patterns. Occult HBV status is associated in some cases with mutant viruses undetectable by HBsAg assays; but more frequently it is due to a strong suppression of viral replication and gene expression. OBI is an entity with world-wide diffusion. The failure to detect HBsAg, despite the persistence of the viral DNA, is due in most cases to the strong suppression of viral replication and gene expression that characterizes this "occult" HBV infection; although the mechanisms responsible for suppression of HBV are not well understood. The majority of OBI cases are secondary to overt HBV infection and represent a residual low viremia level suppressed by a strong immune response together with histological derangements which occurred during acute or chronic HBV infection. Much evidence suggests that it can favour the progression of liver fibrosis and the development of hepatocellular carcinoma.
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