ReviewWorld journal of gastroenterology2011
Nodular regenerative hyperplasia: evolving concepts on underdiagnosed cause of portal hypertension.
Review in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Nodular Regenerative Hyperplasia: Report of 82 Patients and Systematic Review of Literature.United European gastroenterology journal · 2024Pooled it
- Pooled it
- Hepatic control of immunometabolism: implications for the pathogenesis, diagnosis and treatment of rheumatic diseases.Nature reviews. Rheumatology · 2026Review
- Life-Threatening Variceal Bleeding in Antisynthetase Syndrome: Nodular Regenerative Hyperplasia and Porto-Sinusoidal Vascular Disorder.ACG case reports journal · 2026Article
- Hepatic Vascular Involvement in Adenosine Deaminase 2 Deficiency (DADA2): Case Reports and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- A Broad Spectrum of Liver Manifestations in Common Variable Immunodeficiency Syndrome-Two Case Reports and a Literature Overview.Diagnostics (Basel, Switzerland) · 2025Article
- Role of mitogens in normal and pathological liver regeneration.Hepatology communications · 2025Review
- Tubulointerstitial nephritis with IgM-positive plasma cells complicated by liver failure.CEN case reports · 2025Article
- Nodular regenerative hyperplasia: The role of the CK7 immunohistochemistry pattern of expression in diagnosis.American journal of clinical pathology · 2025Article
- Toxicities and management strategies of emerging antibody-drug conjugates in breast cancer.Therapeutic advances in medical oncology · 2025Review
- Rapid Development of Post-Liver Transplantation Nodular Regenerative Hyperplasia and Portal Hypertension After Perfusion Pump Use: A Case Series.Transplantation direct · 2024Article
- Chronic Liver Enzyme Elevation and Use of Contemporary ARVs Among People With HIV.Open forum infectious diseases · 2024Article
- A rare case of liver regenerative and non-neoplastic lesion resembling a well-differentiated hepatocellular carcinoma.Surgical case reports · 2024Article
- Differential Diagnosis: Hepatic Complications in Inborn Errors of Immunity.Journal of clinical medicine · 2023Review
- Generalized crystal-storing histiocytosis with noncirrhotic portal hypertension: an autopsy case report.Clinical journal of gastroenterology · 2023Article
- Nodular Regenerative Hyperplasia of the Liver Associated With Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor in a Patient With Metastatic Renal Cell Carcinoma.JCO precision oncology · 2023Article
- Liver Abnormalities in Turner Syndrome: The Importance of Estrogen Replacement.Journal of the Endocrine Society · 2022Review
- Magnetic Resonance Imaging of Liver Fibrosis, Fat, and Iron.Radiologic clinics of North America · 2022Review
- Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nodular regenerative hyperplasia (NRH) is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules. NRH may lead to the development of non-cirrhotic portal hypertension. There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series. NRH may develop via autoimmune, hematological, infectious, neoplastic, or drug-related causes. The disease is usually asymptomatic, slowly or non-progressive unless complications of portal hypertension develop. Accurate diagnosis is made by histopathology, which demonstrates diffuse micronodular transformation without fibrous septa. Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver. While the initial treatment is to address the underlying disease, ultimately the therapy is directed to the management of portal hypertension. The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension. In this review we detail the epidemiology, pathogenesis, diagnosis, management, and prognosis of NRH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.