Evidence map›Paper›PMID 21472014›Full record

ArticleThe ISME journal2011

Evidence for a core gut microbiota in the zebrafish.

Guus Roeselers, Erika K Mittge, W Zac Stephens, David M Parichy, Colleen M Cavanaugh, Karen Guillemin, John F Rawls

Abstract read
In one paragraph

Article in The ISME journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 506 papers.

0numbers the graph read from it
0cells of the map it votes in
506citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

506 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Environmental science & technology · 2026
    Article
  7. Article
  8. Geometric ordering in bacterial communities.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

446 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guus RoeselersDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Erika K Mittge
W Zac Stephens
David M Parichy
Colleen M Cavanaugh
Karen Guillemin
John F Rawls

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Zebrafish FacilityP01HD022486 · NICHD · UNIVERSITY OF OREGON · PI PARTHASARATHY, RAGHUVEER · 1987 to 2017
$28.8M
ZEBRAFISH INTERNATIONAL RESOURCE CENTERP40RR012546 · NCRR · UNIVERSITY OF OREGON · PI WESTERFIELD, MONTE · 1998 to 2011
$21.9M
Microbial Regulation of Host Nutrient MetabolismR01DK081426 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAWLS, JOHN F · 2008 to 2019
$3.9M
Molecular basis of host-microbiota signaling in the zebrafish gutR01DK075549 · NIDDK · UNIVERSITY OF OREGON · PI GUILLEMIN, KAREN J · 2007 to 2011
$1.8M
Microbial regulation of host nutrient metabolism in gnotobiotic zebrafishK01DK073695 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RAWLS, JOHN F · 2006 to 2009
$510k
NCRR NIH HHS P40 RR012546NCRR NIH HHS RR012546NICHD NIH HHS HD22486NICHD NIH HHS P01 HD022486NIDDK NIH HHS DK073695NIDDK NIH HHS DK075549NIDDK NIH HHS DK081426NIDDK NIH HHS K01 DK073695NIDDK NIH HHS R01 DK075549NIDDK NIH HHS R01 DK081426NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Experimental analysis of gut microbial communities and their interactions with vertebrate hosts is conducted predominantly in domesticated animals that have been maintained in laboratory facilities for many generations. These animal models are useful for studying coevolved relationships between host and microbiota only if the microbial communities that occur in animals in lab facilities are representative of those that occur in nature. We performed 16S rRNA gene sequence-based comparisons of gut bacterial communities in zebrafish collected recently from their natural habitat and those reared for generations in lab facilities in different geographic locations. Patterns of gut microbiota structure in domesticated zebrafish varied across different lab facilities in correlation with historical connections between those facilities. However, gut microbiota membership in domesticated and recently caught zebrafish was strikingly similar, with a shared core gut microbiota. The zebrafish intestinal habitat therefore selects for specific bacterial taxa despite radical differences in host provenance and domestication status.

Indexed as

MetagenomeAnimalsBacteriaGastrointestinal TractIntestinesMolecular Sequence DataRNA, BacterialRNA, Ribosomal, 16SZebrafishRNA, BacterialRNA, Ribosomal, 16S

Identifiers

PMID21472014
PMCPMC3176511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.