ArticleGene therapy2011
Selective atonal gene delivery improves balance function in a mouse model of vestibular disease.
Article in Gene therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 83 citations in OpenAlex.
- Adenovector-mediated gene delivery to human umbilical cord mesenchymal stromal cells induces inner ear cell phenotype.Cellular reprogramming · 2013Trial
- Vestibular hair cell redundancy and the critical requirement of type I cells for balance maintenance.Cellular and molecular life sciences : CMLS · 2026Article
- Article
- Advancing precision ear medicine: leveraging animal models for disease insights and therapeutic innovations.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Current AAV-mediated gene therapy in sensorineural hearing loss.Fundamental research · 2025Review
- Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle.Nature communications · 2024Article
- Roles of supporting cells in the maintenance and regeneration of the damaged inner ear: A literature review.Journal of otology · 2024Review
- Characterization of 3,3'-iminodipropionitrile (IDPN) damaged utricle transcriptome in the adult mouse utricle.Frontiers in molecular neuroscience · 2024Article
- Third-generation lentiviral gene therapy rescues function in a mouse model of Usher 1B.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Subtle alterations of vestibulomotor functioning in conductive hearing loss.Frontiers in neuroscience · 2023Article
- Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration in adult mice.Hearing research · 2022Article
- Repair of surviving hair cells in the damaged mouse utricle.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Co-transduction of dual-adeno-associated virus vectors in the neonatal and adult mouse utricles.Frontiers in molecular neuroscience · 2022Article
- Vestibular Deficits in Deafness: Clinical Presentation, Animal Modeling, and Treatment Solutions.Frontiers in neurology · 2022Review
- Regeneration of Hair Cells in the Human Vestibular System.Frontiers in molecular neuroscience · 2022Review
- Advances in genome editing for genetic hearing loss.Advanced drug delivery reviews · 2021Review
- Quantitative Assessment of Anti-Gravity Reflexes to Evaluate Vestibular Dysfunction in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2019Article
- New molecular therapies for the treatment of hearing loss.Pharmacology & therapeutics · 2019Review
- Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System.Cell reports · 2019Article
- Uncoordinated maturation of developing and regenerating postnatal mammalian vestibular hair cells.PLoS biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Loss of balance is often due to loss of vestibular hair cells. In mammals, regeneration of functional hair cells in the mature sensory epithelium is limited; therefore, loss of sensory cells can lead to debilitating balance problems. Delivery of the transcription factor atonal (atoh1) after aminoglycoside ototoxicity has previously been shown to induce the transdifferentiation of supporting cells into new hair cells and restore function. A problem with mouse aminoglycoside models is that the partial loss of hair cells seen in human disease is difficult to establish consistently. To more closely mirror human clinical balance dysfunction, we have used systemic application of 3,3'-iminodipropionitrile (IDPN), a vestibulotoxic nitrile compound known to cause vestibular hair cell loss, to induce a consistent partial loss of vestibular hair cells. To determine if balance function could be restored, we delivered atoh1 using a new adenovirus vector, based on Ad28. The Ad28 adenovector is based on a human serotype with a low seroprevalence that appears to target gene delivery to vestibular supporting cells. To further provide cell type selectivity of gene delivery, we expressed atoh1 using the supporting cell-specific glial fibrillary acid protein promoter. Delivery of this vector to IDPN-damaged vestibular organs resulted in a significant recovery of vestibular hair cells and restoration of balance, as measured by time on rotarod compared with untreated controls.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.