ArticleNature2011
Crystal structure of a phosphorylation-coupled saccharide transporter.
Article in Nature, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- A trimeric architecture reveals the glucitol PTS transporter as a distinct superfamily.Communications biology · 2026Article
- Chb and nag genes drive N,N'-diacetylchitobiose metabolism in probiotic Lacticaseibacillus paracasei.Applied microbiology and biotechnology · 2026Article
- Structure and mechanism of a phosphotransferase system glucose transporter.Nature communications · 2024Article
- Crystal structure of the NaNature communications · 2022Article
- CHARMM-GUI Drude prepper for molecular dynamics simulation using the classical Drude polarizable force field.Journal of computational chemistry · 2022Article
- Identification of Glycoside Transporters From the Human Gut Microbiome.Frontiers in microbiology · 2022Article
- Harnessing a Transient Gene Expression System inPlants (Basel, Switzerland) · 2021Article
- Transporters of glucose and other carbohydrates in bacteria.Pflugers Archiv : European journal of physiology · 2020Review
- Elevator-type mechanisms of membrane transport.Biochemical Society transactions · 2020Review
- Article
- Substrate-dependent cluster density dynamics of Corynebacterium glutamicum phosphotransferase system permeases.Molecular microbiology · 2019Article
- Cysteine-mediated decyanation of vitamin B12 by the predicted membrane transporter BtuM.Nature communications · 2018Article
- Structure of an EIIC sugar transporter trapped in an inward-facing conformation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Inward-facing conformation of l-ascorbate transporter suggests an elevator mechanism.Cell discovery · 2018Article
- Molecular Simulation and Biochemical Studies Support an Elevator-type Transport Mechanism in EIIC.Biophysical journal · 2017Article
- Enterococcus faecalis Uses a Phosphotransferase System Permease and a Host Colonization-Related ABC Transporter for Maltodextrin Uptake.Journal of bacteriology · 2017Article
- Article
- Glycoscience@Synchrotron: Synchrotron radiation applied to structural glycoscience.Beilstein journal of organic chemistry · 2017Review
- The V-motifs facilitate the substrate capturing step of the PTS elevator mechanism.Journal of structural biology · 2016Article
- The Structure of a Sugar Transporter of the Glucose EIIC Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport.Structure (London, England : 1993) · 2016Article
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Authors and funding
15 authors.
Funding
Abstract
Saccharides have a central role in the nutrition of all living organisms. Whereas several saccharide uptake systems are shared between the different phylogenetic kingdoms, the phosphoenolpyruvate-dependent phosphotransferase system exists almost exclusively in bacteria. This multi-component system includes an integral membrane protein EIIC that transports saccharides and assists in their phosphorylation. Here we present the crystal structure of an EIIC from Bacillus cereus that transports diacetylchitobiose. The EIIC is a homodimer, with an expansive interface formed between the amino-terminal halves of the two protomers. The carboxy-terminal half of each protomer has a large binding pocket that contains a diacetylchitobiose, which is occluded from both sides of the membrane with its site of phosphorylation near the conserved His250 and Glu334 residues. The structure shows the architecture of this important class of transporters, identifies the determinants of substrate binding and phosphorylation, and provides a framework for understanding the mechanism of sugar translocation.
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