Self-propagation and transmission of misfolded mutant SOD1: prion or prion-like phenomenon?

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed.

1. The unfolded protein response in amyotrophic later sclerosis: results of a phase 2 trial.Brain : a journal of neurology · 2021
   Trial
2. Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial).BMJ open · 2017
   Trial
3. The prion-like effect and prion-like protein targeting strategy in amyotrophic lateral sclerosis.Heliyon · 2024
   Review
4. Satellite Glial Cells of the Dorsal Root Ganglion: A New "Guest/Physiopathological Target" in ALS.Frontiers in aging neuroscience · 2020
   Article
5. Application of yeast to studying amyloid and prion diseases.Advances in genetics · 2020
   Review
6. Let's make microglia great again in neurodegenerative disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2018
   Review
7. Neurotoxicity of the Cyanotoxin BMAA Through Axonal Degeneration and Intercellular Spreading.Neurotoxicity research · 2018
   Article
8. Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients.Frontiers in neuroscience · 2018
   Article
9. Prion Properties of SOD1 in Amyotrophic Lateral Sclerosis and Potential Therapy.Cold Spring Harbor perspectives in biology · 2017
   Review
10. The genetics of amyotrophic lateral sclerosis: current insights.Degenerative neurological and neuromuscular disease · 2016
    Review
11. Emerging mechanisms of molecular pathology in ALS.The Journal of clinical investigation · 2015
    Review
12. Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?Experimental neurobiology · 2015
    Review
13. Adeno-associated virus-mediated delivery of a recombinant single-chain antibody against misfolded superoxide dismutase for treatment of amyotrophic lateral sclerosis.Molecular therapy : the journal of the American Society of Gene Therapy · 2014
    Article
14. Cellular aspects of prion replication in vitro.Viruses · 2013
    Review
15. Multifaceted roles of tunneling nanotubes in intercellular communication.Frontiers in physiology · 2012
    Article

Corrections and comments

• Comment on
  Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells.2011

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.