ArticleProceedings of the National Academy of Sciences of the United States of America2011
Alternative mechanisms of receptor editing in autoreactive B cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Explore antibody repertoire in the era of AI.Acta biochimica et biophysica Sinica · 2025Article
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- Mutability and hypermutation antagonize immunoglobulin codon optimality.Molecular cell · 2025Article
- Mechanistic Insights into How the Single Point Mutation Change the Autoantibody Repertoire.The protein journal · 2024Article
- Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus.Nature communications · 2018Article
- Antibody repertoire analysis in polygenic autoimmune diseases.Immunology · 2018Review
- Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis.Annals of the rheumatic diseases · 2018Article
- A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities.Molecular immunology · 2017Article
- Evidence for Ig Light Chain Isotype Exclusion in Shark B Lymphocytes Suggests Ordered Mechanisms.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE.Journal of autoimmunity · 2015Article
- Dual immunoglobulin light chain B cells: Trojan horses of autoimmunity?Current opinion in immunology · 2014Review
- Light chain editors of anti-DNA receptors in human B cells.The Journal of experimental medicine · 2014Article
- VH Replacement Footprint Analyzer-I, a Java-Based Computer Program for Analyses of Immunoglobulin Heavy Chain Genes and Potential VH Replacement Products in Human and Mouse.Frontiers in immunology · 2014Article
- Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Loss of an Igκ gene enhancer in mature B cells results in rapid gene silencing and partial reversible dedifferentiation.Molecular and cellular biology · 2013Article
- Recirculating bone marrow B cells in C57BL/6 mice are more tolerant of highly hydrophobic and highly charged CDR-H3s than those in BALB/c mice.European journal of immunology · 2013Article
- Article
- Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice.The Journal of experimental medicine · 2012Article
- Immunoglobulin analysis tool: a novel tool for the analysis of human and mouse heavy and light chain transcripts.Frontiers in immunology · 2012Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Pathogenic anti-DNA antibodies expressed in systemic lupus erythematosis bind DNA mainly through electrostatic interactions between the positively charged Arg residues of the antibody complementarity determining region (CDR) and the negatively charged phosphate groups of DNA. The importance of Arg in CDR3 for DNA binding has been shown in mice with transgenes coding for anti-DNA V(H) regions; there is also a close correlation between arginines in CDR3 of antibodies and DNA binding. Codons for Arg can readily be formed by V(D)J rearrangement; thereby, antibodies that bind DNA are part of the preimmune repertoire. Anti-DNAs in healthy mice are regulated by receptor editing, a mechanism that replaces κ light (L) chains compatible with DNA binding with κ L chains that harbor aspartic residues. This negatively charged amino acid is thought to neutralize Arg sites in the V(H). Editing by replacement is allowed at the κ locus, because the rearranged VJ is nested between unrearranged Vs and Js. However, neither λ nor heavy (H) chain loci are organized so as to allow such second rearrangements. In this study, we analyze regulation of anti-DNA H chains in mice that lack the κ locus, κ-/κ- mice. These mice show that the endogenous preimmune repertoire does indeed include a high frequency of antibodies with Arg in their CDR3s (putative anti-DNAs) and they are associated mainly with the editor L chain λx. The editing mechanisms in the case of λ-expressing B cells include L chain allelic inclusion and V(H) replacement.
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