ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Functional elimination of excitatory feedforward inputs underlies developmental refinement of visual receptive fields in zebrafish.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Prolonged visual experience accelerates developmental synaptic downscaling via epigenetic regulation and Rab5c mediated AMPA receptor trafficking.Communications biology · 2026Article
- Matching developmental timelines of fish, frog, mouse and human brains.Animal cells and systems · 2026Review
- Decreased GABA levels during development result in increased connectivity in the larval zebrafish tectum.bioRxiv : the preprint server for biology · 2024Article
- Reduction of visual stimulus artifacts using a spherical tank for small, aquatic animals.Scientific reports · 2021Article
- Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling.Scientific reports · 2020Article
- Functional Integration of Newborn Neurons in the Zebrafish Optic Tectum.Frontiers in cell and developmental biology · 2019Review
- Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish.Journal of developmental biology · 2018Article
- Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum.Frontiers in neural circuits · 2018Review
- Strengthening of Direction Selectivity by Broadly Tuned and Spatiotemporally Slightly Offset Inhibition in Mouse Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus.Journal of neurophysiology · 2015Article
- HDAC1 regulates the proliferation of radial glial cells in the developing Xenopus tectum.PloS one · 2015Article
- Functional dissection of synaptic circuits: in vivo patch-clamp recording in neuroscience.Frontiers in neural circuits · 2015Review
- A feedforward inhibitory circuit mediates lateral refinement of sensory representation in upper layer 2/3 of mouse primary auditory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Thresholding of auditory cortical representation by background noise.Frontiers in neural circuits · 2014Article
- Intracortical multiplication of thalamocortical signals in mouse auditory cortex.Nature neuroscience · 2013Article
- Linear transformation of thalamocortical input by intracortical excitation.Nature neuroscience · 2013Article
- Synaptic mechanisms underlying functional dichotomy between intrinsic-bursting and regular-spiking neurons in auditory cortical layer 5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Generation of intensity selectivity by differential synaptic tuning: fast-saturating excitation but slow-saturating inhibition.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- A competition-based mechanism mediates developmental refinement of tectal neuron receptive fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Broadening of inhibitory tuning underlies contrast-dependent sharpening of orientation selectivity in mouse visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
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Abstract
In many sensory systems, receptive fields (RFs) measured by spike responses undergo progressive refinement during development. It has been proposed that elimination of excitatory synaptic inputs underlies such functional refinement. However, despite many extracellular recording and anatomical studies, direct in vivo intracellular evidence has remained limited. In this study, by cell-attached recordings in the developing optic tectum of zebrafish, we found that during a short period after the initial formation of retinotectal synapses, spike visual RFs of tectal neurons underwent a two-stage developmental modulation: from an initial expansion to a later refinement. Whole-cell voltage-clamp recordings revealed that the underlying excitatory synaptic RF exhibited a similar developmental progression, with its spatial extent first increased and then reduced, and its spatial tuning profile gradually sharpened. The inhibitory RF was initially larger than the excitatory RF but became matched with the excitatory RF at later stages. Simulation with the integrate-and-fire neuron model suggested that the developmental changes of excitatory RFs primarily accounted for the initial enlargement and later refinement of spike RFs, whereas inhibitory inputs generally reduced the size of the spike RF without affecting its developmental progression. In addition, spike RF of individual retinal ganglion cells did not significantly change in size during the same period, and the spatial extent and tuning profile of the tectal excitatory RF barely changed after intratectal excitatory connections were silenced. Together, our results demonstrate that the functional refinement of tectal visual RFs results primarily from a selective elimination of feedforward retinotectal inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.