ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Pax6 is required at the telencephalic pallial-subpallial boundary for the generation of neuronal diversity in the postnatal limbic system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
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- Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems.Cell stem cell · 2026Article
- Bidirectional interaction between protocadherin 8 and the transcription factor Dbx1 regulates cerebral cortex development.Development (Cambridge, England) · 2026Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- The dorsoanterior brain of adult amphioxus shares similarities in expression profile and neuronal composition with the vertebrate telencephalon.BMC biology · 2021Article
- Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.Brain structure & function · 2021Article
- Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Novel Perspectives on the Development of the Amygdala in Rodents.Frontiers in neuroanatomy · 2021Review
- A radial histogenetic model of the mouse pallial amygdala.Brain structure & function · 2020Article
- The effects of developmental and current niches on oligodendrocyte precursor dynamics and fate.Neuroscience letters · 2020Review
- Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Loss of Intercalated Cells (ITCs) in the Mouse Amygdala ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Characterization of Glcci1 expression in a subpopulation of lateral ganglionic eminence progenitors in the mouse telencephalon.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Determination of the connectivity of newborn neurons in mammalian olfactory circuits.Cellular and molecular life sciences : CMLS · 2017Review
- A Radial Glia Fascicle Leads Principal Neurons from the Pallial-Subpallial Boundary into the Developing Human Insula.Frontiers in neuroanatomy · 2017Article
- Cell migration in the developing rodent olfactory system.Cellular and molecular life sciences : CMLS · 2016Review
- Current Evidence for Developmental, Structural, and Functional Brain Defects following Prenatal Radiation Exposure.Neural plasticity · 2016Review
- Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development.Nucleic acids research · 2015Article
- Pallial patterning and the origin of the isocortex.Frontiers in neuroscience · 2015Article
- Competing signals drive telencephalon diversity.Nature communications · 2013Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
During embryogenesis, the pallial-subpallial boundary (PSB) divides the two main progenitor domains in the telencephalon: the pallium, the major source of excitatory neurons, and the subpallium, the major source of inhibitory neurons. The PSB is formed at the molecular interface between the pallial (high Pax6+) and subpallial (high Gsx2+) ventricular zone (VZ) compartments. Initially, the PSB contains cells that express both Pax6 and Gsx2, but during later stages of development this boundary is largely refined into two separate compartments. In this study we examined the developmental mechanisms underlying PSB boundary formation and the postnatal consequences of conditional loss of Pax6 function at the PSB on neuronal fate in the amygdala and olfactory bulb, two targets of PSB-derived migratory populations. Our cell fate and time-lapse imaging analyses reveal that the sorting of Pax6+ and Gsx2+ progenitors during embryogenesis is the result of a combination of changes in gene expression and cell movements. Interestingly, we find that in addition to giving rise to inhibitory neurons in the amygdala and olfactory bulb, Gsx2+ progenitors generate a subpopulation of amygdala excitatory neurons. Consistent with this finding, targeted conditional ablation of Pax6 in Gsx2+ progenitors results in discrete local embryonic patterning defects that are linked to changes in the generation of subsets of postnatal excitatory and inhibitory neurons in the amygdala and inhibitory neurons in the olfactory bulb. Thus, in PSB progenitors, Pax6 plays an important role in the generation of multiple subtypes of neurons that contribute to the amygdala and olfactory bulb.
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