ArticleJournal of dental research2011
Apoptotic genes are differentially expressed in aged gingival tissue.
Article in Journal of dental research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 84 citations in OpenAlex.
- Trial
- Sex effects on early life features of the gingival transcriptome.Frontiers in dental medicine · 2025Article
- Single-nucleus transcriptomics uncovers a geroprotective role of YAP in primate gingival aging.Protein & cell · 2024Article
- Sex and Age Effects on Healthy Gingival Transcriptomic Patterns.Journal of dental research · 2023Article
- Gingival transcriptomic patterns of macrophage polarization during initiation, progression, and resolution of periodontitis.Clinical and experimental immunology · 2023Article
- DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues.Frontiers in oral health · 2023Article
- Article
- Comparative Analysis of Gene Expression Patterns for Oral Epithelial Cell Functions in Periodontitis.Frontiers in oral health · 2022Article
- Gingival Transcriptome of Innate Antimicrobial Factors and the Oral Microbiome With Aging and Periodontitis.Frontiers in oral health · 2022Article
- Gingival transcriptomics of follicular T cell footprints in progressing periodontitis.Clinical and experimental immunology · 2021Article
- Transcriptomic phases of periodontitis lesions using the nonhuman primate model.Scientific reports · 2021Article
- Oral microbiome interactions with gingival gene expression patterns for apoptosis, autophagy and hypoxia pathways in progressing periodontitis.Immunology · 2021Article
- Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review.Journal of personalized medicine · 2021Review
- Regulation of Anti-Apoptotic SOD2 and BIRC3 in Periodontal Cells and Tissues.International journal of molecular sciences · 2021Article
- Oral Microbiome and Gingival Gene Expression of Inflammatory Biomolecules With Aging and Periodontitis.Frontiers in oral health · 2021Article
- Oral Microbiome and Gingival Transcriptome Profiles of Ligature-Induced Periodontitis.Journal of dental research · 2020Article
- Oral Microbiome and Gingival Tissue Apoptosis and Autophagy Transcriptomics.Frontiers in immunology · 2020Article
- Periodontal disease susceptible matrilines in the Cayo Santiago Macaca mulatta macaques.Journal of periodontal research · 2019Article
- Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease.Immunobiology · 2019Article
- Gene expression analysis of neuropeptides in oral mucosa during periodontal disease in non-human primates.Journal of periodontology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Cellular and molecular changes of the periodontium associated with a higher prevalence of oral diseases (e.g., chronic periodontitis) in aged populations have received little attention. Since impaired apoptosis during aging appears to be related to chronic inflammatory disorders, we hypothesized that the expression of genes associated with apoptotic processes are altered in aged healthy and periodontitis-affected gingival tissue. Ontology analysis of 88 genes related to apoptotic pathways was performed in gingival biopsies of healthy and periodontitis sites from young, adult, and aged non-human primates (Macaca mulatta), using the GeneChip® Rhesus Macaque Genome Array. Lower expression of anti-apoptotic and higher expression of pro-apoptotic genes were associated with healthy gingival tissue from young compared with aged animals. Few differences in gene expression were observed in healthy gingival tissue between adult and aged animals. Comparison between healthy and periodontitis gingival tissues showed that the up- or down-regulated apoptotic genes in diseased gingival tissue are different in adults compared with aged animals. These results suggest that apoptotic events normally occurring in gingival tissues could be reduced in aging,and unique aspects of apoptotic pathways are potentially involved in the pathophysiology of periodontal disease in adult vs. aged gingival tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.