ArticleAmerican journal of respiratory and critical care medicine2011
c-Kit is essential for alveolar maintenance and protection from emphysema-like disease in mice.
Article in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture.Journal of tissue engineering and regenerative medicine · 2013Trial
- Fetal hypoplastic lungs have multilineage inflammation that is reversed by amniotic fluid stem cell extracellular vesicle treatment.Science advances · 2024Article
- C-KitIranian journal of basic medical sciences · 2022Article
- Tissue distribution of stem cell factor in adults.Experimental and molecular pathology · 2021Article
- Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3.Science translational medicine · 2021Article
- Lung Function in African American Children with Asthma Is Associated with Novel Regulatory Variants of the KIT LigandGenetics · 2020Article
- Identification of Epigenetic Mechanisms Involved in the Anti-Asthmatic Effects ofMolecules (Basel, Switzerland) · 2018Article
- A candidate gene identification strategy utilizing mouse to human big-data mining: "3R-tenet" in COPD genetic research.Respiratory research · 2018Article
- Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function.Respiratory research · 2017Article
- iPSC-derived mesenchymal stem cells exert SCF-dependent recovery of cigarette smoke-induced apoptosis/proliferation imbalance in airway cells.Journal of cellular and molecular medicine · 2017Article
- New Role of Adult Lung c-kitMediators of inflammation · 2016Article
- Expression of Concern: TLR4 Is Necessary for Hyaluronan-mediated Airway Hyperresponsiveness after Ozone Inhalation; c-Kit Is Essential for Alveolar Maintenance and Protection from Emphysema-like Disease in Mice.American journal of respiratory and critical care medicine · 2015Article
- Secreted phosphoprotein 1 is a determinant of lung function development in mice.American journal of respiratory cell and molecular biology · 2014Article
- Mast cell-deficient kit mice develop house dust mite-induced lung inflammation despite impaired eosinophil recruitment.Journal of innate immunity · 2014Article
- Stem cell factor improves lung recovery in rats following neonatal hyperoxia-induced lung injury.Pediatric research · 2013Article
- Concise review: clinical prospects for treating chronic obstructive pulmonary disease with regenerative approaches.Stem cells translational medicine · 2012Review
- RETRACTED: NAD(P)H:quinone oxidoreductase 1 protects lungs from oxidant-induced emphysema in mice.Free radical biology & medicine · 2012Article
Corrections and comments
- Expression of concern · 2015-09-15Concerns/Issues about Data · Investigation by Journal/Publisher · Objections by Author(s) · Unreliable Data · · For EN Potts, see also EN Potts-Kant; See also Comment on Expression of Concern: http://www.atsjournals.org/doi/abs/10.1164/rccm.1935comment;
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
rationalePreviously, we demonstrated a candidate region for susceptibility to airspace enlargement on mouse chromosome 5. However, the specific candidate genes within this region accounting for emphysema-like changes remain unrecognized. c-Kit is a receptor tyrosine kinase within this candidate gene region that has previously been recognized to contribute to the survival, proliferation, and differentiation of hematopoietic stem cells. Increases in the percentage of cells expressing c-Kit have previously been associated with protection against injury-induced emphysema.
objectivesDetermine whether genetic variants of c-Kit are associated with spontaneous airspace enlargement.
methodsPerform single-nucleotide polymorphism association studies in the mouse strains at the extremes of airspace enlargement phenotype for variants in c-Kit tyrosine kinase. Characterize mice bearing functional variants of c-Kit compared with wild-type controls for the development of spontaneous airspace enlargement. Epithelial cell proliferation was measured in culture. MEASUREMENTS AND MAIN
resultsUpstream regulatory single-nucleotide polymorphisms in the divergent mouse strains were associated with the lung compliance difference observed between the extreme strains. c-Kit mutant mice (Kit(W-sh)/(W-sh)), when compared with genetic controls, developed altered lung histology, increased total lung capacity, increased residual volume, and increased lung compliance that persist into adulthood. c-Kit inhibition with imatinib attenuated in vitro proliferation of cells expressing epithelial cell adhesion molecule.
conclusionsOur findings indicate that c-Kit sustains and/or maintains normal alveolar architecture in the lungs of mice. In vitro data suggest that c-Kit can regulate epithelial cell clonal expansion. The precise mechanisms that c-Kit contributes to the development of airspace enlargement and increased lung compliance remain unclear and warrants further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.