Evidence map›Paper›PMID 21471066›Full record

GuidelineAmerican journal of respiratory and critical care medicine2011

An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management.

Ganesh Raghu, Harold R Collard, Jim J Egan, Fernando J Martinez, Juergen Behr, Kevin K Brown, Thomas V Colby, Jean-François Cordier, Kevin R Flaherty, Joseph A Lasky and 24 more

21 registry-linked trialsAbstract readPractice Guideline
In one paragraph

Guideline in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 21 registered trials, which are not on this map. Cited by 3,311 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3,311citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01600378 recruitingnot on this mapstarted 2012, after this paper: background citation

Prospective Data Collection of Clinical, Pulmonary Function, Radiological, Bronchoscopic and Fibered Confocal Fluorescence Microscopy Imaging, and Pathological Characteristics in Patients With Diffuse Parenchymal Lung Diseases

TypeobservationalSponsorSingapore General HospitalRan2012 to 2030Enrolled500ConditionsDiffuse Parenchymal Lung Diseases
NCT01714518 completednot on this mapstarted 2012, after this paper: background citation

Cryobiopsy vs. VATS: Efficiency and Safety in the Diagnosis of Interstitial Lung Diseases

TypeobservationalSponsorWissenschaftliches Institut Bethanien e.VRan2012 to 2017Enrolled62ConditionsInterstitial Lung Disease
NCT01738711 naunknown statusnot on this mapstarted 2012, after this paper: background citation

Does Cognitive Behavioural Therapy (CBT) Delivered by a Respiratory Nurse Reduce Anxiety and the Impact of Cough and Breathlessness on Quality of Life in Patients With Idiopathic Pulmonary Fibrosis (IPF)?

TypeinterventionalSponsorRoyal Victoria InfirmaryRan2012 to 2014Enrolled30ConditionsIdiopathic Pulmonary Fibrosis, Cough, BreathlessnessArmsCognitive behavioural therapy
NCT02460588 phase3completednot on this mapstarted 2015, after this paper: background citation

Cyclophosphamide Added to Corticosteroid in the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Placebo-controlled Randomized Trial

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2015 to 2019Enrolled120ConditionsIdiopathic Pulmonary FibrosisArmsCyclophosphamide, Placebo, Corticosteroid (prednisolone)
NCT02645968 completednot on this mapstarted 2014, after this paper: background citation

Registry for Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases - EXCITING

Typeobservational_patient_registrySponsorHeidelberg UniversityRan2014 to 2020Enrolled600ConditionsInterstitial Lung Disease (ILD)
NCT02755441 active not recruitingnot on this mapstarted 2016, after this paper: background citation

Pulmonary Fibrosis Biomarker Cohort (PFBIO)

TypeobservationalSponsorNils HoyerRan2016 to 2028Enrolled450ConditionsIdiopathic Pulmonary Fibrosis
NCT02772549 active not recruitingnot on this mapstarted 2016, after this paper: background citation

Early Diagnosis of Pulmonary Fibrosis

Typeobservational_patient_registrySponsorNils HoyerRan2016 to 2028Enrolled300ConditionsIdiopathic Pulmonary Fibrosis
NCT02821039 terminatednot on this mapstarted 2016, after this paper: background citation

Turkish Thoracic Society Usual Interstitial Pneumonia Registry Study

Typeobservational_patient_registrySponsorTurkish Thoracic SocietyRan2016 to 2019Enrolled1,678ConditionsIdiopathic Pulmonary Fibrosis, Usual Interstitial Pneumonia
NCT03268915 nacompletednot on this mapstarted 2017, after this paper: background citation

Assessment of the Reproducibility of the 3 Minutes Sit-to-stand Test in Patients With Idiopathic Pulmonary Fibrosis (IPF)

TypeinterventionalSponsorUniversity Hospital, GrenobleRan2017 to 2018Enrolled35ConditionsIdiopathic Pulmonary FibrosisArms3 minutes sit-to-stand test
NCT03274544 naterminatednot on this mapstarted 2018, after this paper: background citation

The Effectiveness of an Empirical Chinese Medicine Formulation for Idiopathic Pulmonary Fibrosis: an Open Label Clinical Trial

TypeinterventionalSponsorThe University of Hong KongRan2018 to 2020Enrolled6ConditionsIdiopathic Pulmonary FibrosisArmsPROLUNG
NCT03480451 naterminatednot on this mapstarted 2017, after this paper: background citation

Targeted Intervention for Patient Centered Outcome in Patients With Idiopathic Pulmonary Fibrosis

TypeinterventionalSponsorMedical College of WisconsinRan2017 to 2019Enrolled1ConditionsIdiopathic Pulmonary FibrosisArmsMulti-Disciplinary Patient Centered Rehab and Education
NCT03596528 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Interstitial Lung Disease (ILD). Comparative Study of the Diagnostic Yield of Surgical Lung Biopsy Versus Cryobiopsy.

TypeinterventionalSponsorHospital Clinic of BarcelonaRan2018 to 2018Enrolled40ConditionsLung Diseases, InterstitialArmsLung biopsy
NCT03732859 completednot on this mapstarted 2018, after this paper: background citation

A Prospective Observational Registry to Describe the Disease Course and Outcomes of Idiopathic Pulmonary Fibrosis Patients in a Real-world Clinical Setting. PROOF-Registry New and Extended Belgium -Luxembourg

Typeobservational_patient_registrySponsorBelgian Thoracic SocietyRan2018 to 2022Enrolled575ConditionsIdiopathic Pulmonary Fibrosis
NCT04244734 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Implementation of an Early Rehabilitation Program for the Patient With Lung Transplantation: From the ICU to Home.

TypeinterventionalSponsorHospital Universitari Vall d'Hebron Research InstituteRan2019 to 2021Enrolled85ConditionsLung Transplant, RehabilitationArmsUsual care treatment, New Treatment Protocol-MotoMED®
NCT04619199 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Influence of Socioeconomic and Environmental Factors on the Natural History of Idiopathic Pulmonary Fibrosis

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2021 to 2025Enrolled200ConditionsIdiopathic Pulmonary Fibrosis, Pulmonary Disease, Pulmonary MedicineArmsBlood sample
NCT04803617 completednot on this mapstarted 2017, after this paper: background citation

The Effect of Pectoralis Muscle Strength on Pulmonary Function in Elderly With Interstitial Lung Disease

TypeobservationalSponsorHabibedurduRan2017 to 2017Enrolled68ConditionsInterstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Sarcoidosis, Pulmonary, GeriatricArmsAssessment of pulmonary function and pectoralis muscle strength
NCT05468502 phase1completednot on this mapstarted 2022, after this paper: background citation

An Open Clinical Study to Explore the Safety, Tolerance and Preliminary Efficacy of Human Umbilical Cord Mesenchymal Stem Cell Injection in the Treatment of Idiopathic Pulmonary Fibrosis (IPF)

TypeinterventionalSponsorShanghai Life Science & TechnologyRan2022 to 2025Enrolled17ConditionsIdiopathic Pulmonary FibrosisArmsHuman umbilical cord mesenchymal stem cell injection
NCT05674994 phase3recruitingnot on this mapstarted 2023, after this paper: background citation

Glucocorticoids Versus Placebo for the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis: a Randomized Controlled Trial

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2023 to 2026Enrolled110ConditionsAcute Exacerbation of Idiopathic Pulmonary FibrosisArmsMethylprednisone/Prednisone, Placebo
NCT05828953 phase2active not recruitingnot on this mapstarted 2021, after this paper: background citation

A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial of Anlotinib Capsules for the Treatment of Idiopathic Pulmonary Fibrosis (IPF)/Progressive Fibrosis-interstitial Lung Disease (PF-ILDs)

TypeinterventionalSponsorFirst Affiliated Hospital of Wenzhou Medical UniversityRan2021 to 2026Enrolled30ConditionsInterstitial Lung DiseasesArmsAnlotinib, Placebo
NCT06465654 nacompletednot on this mapstarted 2024, after this paper: background citation

OXYWILD - Automated Oxygen Titration With O2matic During Walking in Patients With Fibrotic Interstitial Lung Diseases (F-ILD): A Randomized Study

TypeinterventionalSponsorJanne Hastrup JensenRan2024 to 2025Enrolled29ConditionsFibrosis Lung, Respiratory TherapyArmsAutomated variable dose oxygen treatment, Fixed dose oxygen treatment
NCT07315425 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Investigation of the Acute Effects of Blood Flow Restriction Aerobic Exercise on Hemodynamic Responses and Muscle Oxygen in Patients With Interstitial Lung Disease

TypeinterventionalSponsorGazi UniversityRan2026 to 2028Enrolled30ConditionsInterstitial Lung Disease (ILD)ArmsBlood flow restriction (BFR) low-intensity aerobic exercise training, Low-intensity aerobic exercise training
3 · Its place in the literature

Who cites it

3,311 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Clinical care in interstitial lung disease: a critical appraisal of clinical guidance documents.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  11. Pharmacokinetics and Safety of Nerandomilast in Healthy Volunteers.European journal of drug metabolism and pharmacokinetics · 2026
    Trial
  12. Trial
  13. Article
  14. Article
  15. Article
  16. Article
  17. Acute exacerbation in fibrotic interstitial lung disease: an international working group report.American journal of respiratory and critical care medicine · 2026
    Review
  18. Article
  19. Article
  20. Article

3,251 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors.

Ganesh Raghu
Harold R Collard
Jim J Egan
Fernando J Martinez
Juergen Behr
Kevin K Brown
Thomas V Colby
Jean-François Cordier
Kevin R Flaherty
Joseph A Lasky
David A Lynch
Jay H Ryu
Jeffrey J Swigris
Athol U Wells
Julio Ancochea
Demosthenes Bouros
Carlos Carvalho
Ulrich Costabel
Masahito Ebina
David M Hansell
Takeshi Johkoh
Dong Soon Kim
Talmadge E King
Yasuhiro Kondoh
Jeffrey Myers
Nestor L Müller
Andrew G Nicholson
Luca Richeldi
Moisés Selman
Rosalind F Dudden
Barbara S Griss
Shandra L Protzko
Holger J Schünemann
ATS/ERS/JRS/ALAT Committee on Idiopathic Pulmonary Fibrosis

Funding

Pulmonary Rehabilitation for Idiopathic Pulmonary FibrosisK23HL092227 · NHLBI · NATIONAL JEWISH HEALTH · PI SWIGRIS, JEFFREY J · 2009 to 2013
$657k
NHLBI NIH HHS K23 HL092227
6 · The paper itself

Abstract

This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association. It represents the current state of knowledge regarding idiopathic pulmonary fibrosis (IPF), and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course. For the diagnosis and treatment sections, pragmatic GRADE evidence-based methodology was applied in a question-based format. For each diagnosis and treatment question, the committee graded the quality of the evidence available (high, moderate, low, or very low), and made a recommendation (yes or no, strong or weak). Recommendations were based on majority vote. It is emphasized that clinicians must spend adequate time with patients to discuss patients' values and preferences and decide on the appropriate course of action.

Indexed as

Evidence-Based MedicineEuropeHumansIdiopathic Pulmonary FibrosisInternational CooperationJapanLatin AmericaSocieties, MedicalUnited States

Identifiers

PMID21471066
PMCPMC5450933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 15 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.