ArticleCarcinogenesis2011
A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas.
Article in Carcinogenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Clinical Characteristics, Patterns of Care, and Treatment Outcomes of Radiation-Associated Sarcomas.Cancers · 2024Article
- Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Histology-Specific Prognostication for Radiation-Associated Soft Tissue Sarcoma.JCO precision oncology · 2022Article
- Total-Body Irradiation Is Associated With Increased Incidence of Mesenchymal Neoplasia in a Radiation Late Effects Cohort of Rhesus Macaques (Macaca mulatta).International journal of radiation oncology, biology, physics · 2022Article
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans.Journal of pineal research · 2021Article
- Genomic Characterization of Radiation-Induced Intracranial Undifferentiated Pleomorphic Sarcoma.Case reports in genetics · 2021Article
- Review
- Gene expression profiles of esophageal squamous cell cancers in Hodgkin lymphoma survivors versus sporadic cases.PloS one · 2020Article
- Genomic and transcriptomic comparison of post-radiation versus sporadic sarcomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Radiation-Induced Sarcoma of the Head and Neck: A Review of the Literature.Frontiers in oncology · 2018Review
- Mutational signatures of ionizing radiation in second malignancies.Nature communications · 2016Article
- Radiation-Induced Sarcoma: A 15-Year Experience in a Single Large Tertiary Referral Center.Cancer research and treatment · 2016Article
- HZE Radiation Non-Targeted Effects on the Microenvironment That Mediate Mammary Carcinogenesis.Frontiers in oncology · 2016Review
- Radiation-Associated Undifferentiated Pleomorphic Sarcoma is Associated with Worse Clinical Outcomes than Sporadic Lesions.Annals of surgical oncology · 2015Article
- Radiation-induced sarcomas of the head and neck.World journal of clinical oncology · 2014Review
- Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas.Korean journal of pathology · 2014Article
- Aberrations in Angiogenic Signaling and MYC Amplifications are Distinguishing Features of Angiosarcoma.Angiology: open access · 2013Article
- Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer.Annals of surgical oncology · 2013Article
- Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic subtypes.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Article
- Sarcoma risk after radiation exposure.Clinical sarcoma research · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to ionizing radiation is a known risk factor for cancer. However, up to now, rigorously defined scientific criteria that could establish case-by-case the radiation-induced (RI) origin of a tumour have been lacking. To identify genes that could constitute a RI signature, we compared the transcriptome of 12 sarcomas arising in the irradiation field of a primary tumour following radiotherapy with the transcriptome of 12 sporadic sarcomas. This learning/training set contained four leiomyosarcomas, four osteosarcomas and four angiosarcomas in each subgroup. We identified a signature of 135 genes discriminating RI from sporadic sarcomas. The robustness of this signature was tested by the blind case-by-case classification of an independent set of 36 sarcomas of various histologies. Thirty-one sarcomas were classified as RI or sporadic; it was not possible to propose an aetiology for the five others. After the code break, it was found that one sporadic sarcoma was misclassified as RI. Thus, the signature is robust with a sensitivity of 96%, a positive and a negative predictive value of 96 and 100%, respectively and a specificity of 62%. The functions of the genes of the signature suggest that RI sarcomas were subject to chronic oxidative stress probably due to mitochondrial dysfunction.
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