ArticleMolecular and biochemical parasitology
Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine.
Article in Molecular and biochemical parasitology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- An Antiparasitic Compound from the Medicines for Malaria Venture Pathogen Box PromotesACS infectious diseases · 2020Article
- Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.Cell chemical biology · 2020Article
- Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor.Scientific reports · 2019Article
- Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs.ACS infectious diseases · 2018Article
- Article
- A Variant PfCRT Isoform Can Contribute tomBio · 2017Article
- Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins.Journal of cell science · 2016Article
- High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations.Scientific reports · 2015Article
- Determination of the cytostatic and cytocidal activities of antimalarial compounds and their combination interactions.Current protocols in chemical biology · 2014Article
- To kill or not to kill, that is the question: cytocidal antimalarial drug resistance.Trends in parasitology · 2014Article
- Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis.Malaria journal · 2013Article
- Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.Biochemistry · 2013Article
- Altered temporal response of malaria parasites determines differential sensitivity to artemisinin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1).Journal of natural products · 2013Article
- Evaluation of bioluminescence-based assays of anti-malarial drug activity.Malaria journal · 2013Article
- Relative to quinine and quinidine, their 9-epimers exhibit decreased cytostatic activity and altered heme binding but similar cytocidal activity versus Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2013Article
- Autophagy in Plasmodium, a multifunctional pathway?Computational and structural biotechnology journal · 2013Review
- A process similar to autophagy is associated with cytocidal chloroquine resistance in Plasmodium falciparum.PloS one · 2013Article
- Cytostatic versus cytocidal activities of chloroquine analogues and inhibition of hemozoin crystal growth.Antimicrobial agents and chemotherapy · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
With one exception (Gligorijevic et al., Mol Biochem Parasitol 2008;159:7-23.) all previous quantification of chloroquine (CQ) potency vs. P. falciparum has been by growth inhibition assays, meaning potency is defined as cytostatic potential and quantified by IC(50) values. In this study we investigate the cytocidal potency of CQ and other common quinoline antimalarial drugs (quantified as LD(50)). Similar to results from assays for cytostatic potency, we are able to readily distinguish drug resistant from drug sensitive P. falciparum parasites as well as different degrees of resistance. However, we find that fold-resistance to CQ and other quinoline drugs quantified via LD(50) ratios differs quite dramatically from fold resistance calculated via IC(50) ratios. Also, importantly, we find that verapamil chemoreversal of CQ resistance differs when quantified via cytocidal vs. cytostatic assays, as do patterns of "multidrug" resistance in well-known laboratory strains of P. falciparum. The results have important implications for development of new antimalarial drugs and for fully defining the genetic loci that confer clinically relevant antimalarial drug resistance phenomena.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.