ArticleBMC evolutionary biology2011
Expression level, cellular compartment and metabolic network position all influence the average selective constraint on mammalian enzymes.
Article in BMC evolutionary biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Article
- Gene connectivity and enzyme evolution in the human metabolic network.Biology direct · 2019Article
- Functional characterization of SMN evolution in mouse models of SMA.Scientific reports · 2019Article
- Metabolic Determinants of Enzyme Evolution in a Genome-Scale Bacterial Metabolic Network.Genome biology and evolution · 2018Article
- Correlates of evolutionary rates in the murine sperm proteome.BMC evolutionary biology · 2018Article
- Influence of pathway topology and functional class on the molecular evolution of human metabolic genes.PloS one · 2018Article
- Network Architecture and Mutational Sensitivity of theFrontiers in molecular biosciences · 2018Article
- Diet shifts provoke complex and variable changes in the metabolic networks of the ruminal microbiome.Microbiome · 2017Article
- The players may change but the game remains: network analyses of ruminal microbiomes suggest taxonomic differences mask functional similarity.Nucleic acids research · 2015Article
- Three independent determinants of protein evolutionary rate.Journal of molecular evolution · 2013Review
- Flagellated algae protein evolution suggests the prevalence of lineage-specific rules governing evolutionary rates of eukaryotic proteins.Genome biology and evolution · 2013Article
- A conserved mammalian protein interaction network.PloS one · 2013Article
- The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution.BMC evolutionary biology · 2012Article
- Selection for higher gene copy number after different types of plant gene duplications.Genome biology and evolution · 2011Article
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2 authors.
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Abstract
backgroundA gene's position in regulatory, protein interaction or metabolic networks can be predictive of the strength of purifying selection acting on it, but these relationships are neither universal nor invariably strong. Following work in bacteria, fungi and invertebrate animals, we explore the relationship between selective constraint and metabolic function in mammals.
resultsWe measure the association between selective constraint, estimated by the ratio of nonsynonymous (Ka) to synonymous (Ks) substitutions, and several, primarily metabolic, measures of gene function. We find significant differences between the selective constraints acting on enzyme-coding genes from different cellular compartments, with the nucleus showing higher constraint than genes from either the cytoplasm or the mitochondria. Among metabolic genes, the centrality of an enzyme in the metabolic network is significantly correlated with Ka/Ks. In contrast to yeasts, gene expression magnitude does not appear to be the primary predictor of selective constraint in these organisms.
conclusionsOur results imply that the relationship between selective constraint and enzyme centrality is complex: the strength of selective constraint acting on mammalian genes is quite variable and does not appear to exclusively follow patterns seen in other organisms.
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