ArticleFibrogenesis & tissue repair2011
Epithelial to mesenchymal transition as a biomarker in renal fibrosis: are we ready for the bedside?
Article in Fibrogenesis & tissue repair, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 82 citations in OpenAlex.
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- The Mechanism of Hyperglycemia-Induced Renal Cell Injury in Diabetic Nephropathy Disease: An Update.Life (Basel, Switzerland) · 2023Review
- Persistence Infection of TGEV PromotesInternational journal of molecular sciences · 2022Article
- Hormonal Regulation of Renal Fibrosis.Life (Basel, Switzerland) · 2022Review
- Cellular phenotypic transitions in diabetic nephropathy: An update.Frontiers in pharmacology · 2022Review
- ShenKang Injection Attenuates Renal Fibrosis by Inhibiting EMT and Regulating the Wnt/Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Hyperuricemia and Progression of Chronic Kidney Disease: A Review from Physiology and Pathogenesis to the Role of Urate-Lowering Therapy.Diagnostics (Basel, Switzerland) · 2021Review
- Review
- Therapeutic Targeting of Fibrotic Epithelial-Mesenchymal Transition-An Outstanding Challenge.Frontiers in pharmacology · 2019Review
- Traditional Chinese Medicine and regulatory roles on epithelial-mesenchymal transitions.Chinese medicine · 2019Review
- Expression of β-catenin in regenerating renal tubules of cisplatin-induced kidney failure in rats.Clinical and experimental nephrology · 2018Article
- CERA Attenuates Kidney Fibrogenesis in the db/db Mouse by Influencing the Renal Myofibroblast Generation.Journal of clinical medicine · 2018Article
- Effects of Qingshen Granules on the Oxidative Stress-NF/kB Signal Pathway in Unilateral Ureteral Obstruction Rats.Evidence-based complementary and alternative medicine : eCAM · 2018Article
- Reactive oxygen species modulator 1 regulates oxidative stress and induces renal and pulmonary fibrosis in a unilateral ureteral obstruction rat model and in HK‑2 cells.Molecular medicine reports · 2017Article
- Role of Epigenetic Histone Modifications in Diabetic Kidney Disease Involving Renal Fibrosis.Journal of diabetes research · 2017Review
- Review
- Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age.American journal of physiology. Renal physiology · 2015Article
- How tubular epithelial cells dictate the rate of renal fibrogenesis?World journal of nephrology · 2015Review
- Klotho gene delivery ameliorates renal hypertrophy and fibrosis in streptozotocin-induced diabetic rats by suppressing the Rho-associated coiled-coil kinase signaling pathway.Molecular medicine reports · 2015Article
- Epigenetic repression of Krüppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis.International journal of molecular medicine · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past two decades, the concept of the epithelial to mesenchymal transition (EMT) has been imported from embryology and oncology to fibrosis, particularly in the kidney. This interest in EMT in the context of renal fibrosis stems from observations of epithelial cells undergoing phenotypic changes reminiscent of fibroblasts. Whether EMT is actually a source of interstitial fibroblasts has been the subject of heated debate, and this controversy has caused physicians to neglect the value of EMT as a biomarker in renal fibrosis. In this review, we describe the evolution of the techniques used to detect EMT during fibrosing renal diseases, and what information they provide in the diagnosis of various renal diseases. Highlighting the great heterogeneity of these techniques and the need to standardize them, we warn against some misleading uses of EMT markers. We suggest using the association of vimentin and β-catenin for the diagnosis of EMT in renal pathology because it is both sensitive and prognostic, thus satisfying the properties required for a screening test. Finally, we discuss the potential interests to diagnose EMT for the comprehension of renal fibrosis and for clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.