Evidence map›Paper›PMID 21470348›Full record

ArticleTropical medicine & international health : TM & IH2011

Causes of stillbirth, neonatal death and early childhood death in rural Zambia by verbal autopsy assessments.

Eleanor Turnbull, Mwila K Lembalemba, M Brad Guffey, Carolyn Bolton-Moore, Mwangelwa Mubiana-Mbewe, Namwinga Chintu, Mark J Giganti, Mutinta Nalubamba-Phiri, Elizabeth M Stringer, Jeffrey S A Stringer and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in Tropical medicine & international health : TM & IH, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00753428 (CIDRZ 1236 - Community-based Evaluation of a Pilot PMTCT Project in Kafue District), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00753428 completednot on this map

CIDRZ 1236 - Community-based Evaluation of a Pilot PMTCT Project in Kafue District: Impact of HAART to Prevent Pediatric AIDS in Rural Zambia.

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2008 to 2011Enrolled4,129ConditionsDeath, HIV InfectionArmsCommunity-based Survey
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Perinatal mortality in eastern Africa: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Ambient temperature and stillbirth risks in northern Sweden, 1880-1950.Environmental epidemiology (Philadelphia, Pa.) · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Risk of stillbirth among Zambian women with a prior cesarean delivery.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eleanor TurnbullCentre for Infectious Disease Research in Zambia, Lusaka, Zambia.
Mwila K Lembalemba
M Brad Guffey
Carolyn Bolton-Moore
Mwangelwa Mubiana-Mbewe
Namwinga Chintu
Mark J Giganti
Mutinta Nalubamba-Phiri
Elizabeth M Stringer
Jeffrey S A Stringer
Benjamin H Chi

Funding

Virology CoreP30AI027767 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul A. Goepfert · 1988 to 2026
$84.1M
Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Vanderbilt University-CIDRZ AIDS International Training and Research ProgramD43TW001035 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 1998 to 2014
$10.9M
A Training Program in International Women's HealthK01TW006670 · FIC · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHI, BENJAMIN H. · 2005 to 2009
$512k
FIC NIH HHS D43 TW001035FIC NIH HHS D43-TW001035FIC NIH HHS K01 TW006670FIC NIH HHS K01-TW06670FIC NIH HHS R24 TW007988FIC NIH HHS R24-TW007988NIAID NIH HHS P30 AI027767NIAID NIH HHS P30-AI027767
6 · The paper itself

Abstract

objectivesTo describe specific causes of the high rates of stillbirth, neonatal death and early child childhood death in Zambia.

methodsWe conducted a household-based survey in rural Zambia. Socio-demographic and delivery characteristics were recorded, alongside a maternal HIV test. Verbal autopsy questionnaires were administered to elicit mortality-related information and independently reviewed by three experienced paediatricians who assigned a cause and contributing factor to death. For this secondary analysis, deaths were categorized into: stillbirths (foetal death ≥28 weeks of gestation), neonatal deaths (≤28 days) and early childhood deaths (>28 days to <2 years).

resultsAmong 1679 households, information was collected on 148 deaths: 34% stillbirths, 26% neonatal and 40% early childhood deaths. Leading identifiable causes of stillbirth were intrauterine infection (26%) and birth asphyxia (18%). Of 32 neonatal deaths, 38 (84%) occurred within the first week of life, primarily because of infections (37%) and prematurity (34%). The majority of early childhood deaths were caused by suspected bacterial infections (82%). HIV prevalence was significantly higher in mothers who reported an early childhood death (44%) than mothers who did not (17%; P < 0.01). Factors significantly associated with mortality were lower socio-economic status (P < 0.01), inadequate water or sanitation facilities (P < 0.01), home delivery (P = 0.04) and absence of a trained delivery attendant (P < 0.01).

conclusionWe provide community-level data about the causes of death among children under 2 years of age. Infectious etiologies for mortality ranked highest. At a public health level, such information may have an important role in guiding prevention and treatment strategies to address perinatal and early childhood mortality.

Indexed as

Cause of DeathAutopsyFemaleFetal DeathHumansInfantInfant MortalityInfant, NewbornInfectionsMaleRural PopulationStillbirthSurveys and QuestionnairesZambia

Identifiers

PMID21470348
PMCPMC3594698

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.