ReviewAnnual review of neuroscience2011
Modulation of striatal projection systems by dopamine.
Review in Annual review of neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 987 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
The Effect of Dopaminergic Modulation on Brain Computer Interface Efficacy
Who cites it
987 citing papers in PubMed.
- Safety and Effect of 12-Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome.Movement disorders clinical practice · 2025Trial
- Dopamine amplifies subthalamic long-latency responses to cortical stimulation in patients with Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Effects of oxycodone on tonic levels and phasic release of serotonin in the rat nucleus accumbens core.Bioelectrochemistry (Amsterdam, Netherlands) · 2026Article
- Article
- Systemic AR-C155858 During Fixed Treadmill Exercise in MPTP Mice: An Exploratory Study.Neurochemical research · 2026Article
- Coordinated yet asymmetric striatal neuromodulatory dynamics encode associative learning.bioRxiv : the preprint server for biology · 2026Article
- Nucleus accumbens CD81 regulates methamphetamine-induced locomotor activity, conditioned reward, and reinstatement in male and female rats.Psychopharmacology · 2026Article
- Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices.Nature communications · 2026Article
- What can clinical disorders involving the basal ganglia tell us about the pathophysiology of obsessive and compulsive symptoms?Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Acquisition-Recruited and MOR-Expressing Striatal dMSNs Differentially Regulate Extinction and Cue-Induced Relapse of Alcohol Seeking.Addiction biology · 2026Article
- Noninvasive Mapping of Striosome-Matrix Imbalance in Early Psychosis.Biological psychiatry global open science · 2026Article
- Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026Article
- Nigrostriatal dopaminergic vulnerability in Parkinson's disease: Neuroprotective strategies.Neural regeneration research · 2026Article
- Striatal pathways dissociably control action counting and goal-directed steering.Nature neuroscience · 2026Article
- Indirect pathway neurons in the tail of the striatum regulate inhibitory control over sensory driven behavior.Science advances · 2026Article
- Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning.Science advances · 2026Article
- Association between aperiodic activity and impulsivity in individuals with methamphetamine use disorder.Psychopharmacology · 2026Article
- Brain-wide mapping and region-specific cellular characterization of Trhr1 reporter-labeled cells in mice using VISoR imaging.Brain structure & function · 2026Article
- Lactate dynamics in Parkinson's disease: striatal circuit vulnerability, biomarker potential, and therapeutic windows.Molecular medicine (Cambridge, Mass.) · 2026Review
- Striatal remodeling in Parkinson disease.The Journal of pharmacology and experimental therapeutics · 2026Article
927 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal projection systems--so-called direct and indirect pathways--form the functional backbone of the basal ganglia circuit. Twenty years ago, investigators proposed that the striatum's ability to use dopamine (DA) rise and fall to control action selection was due to the segregation of D(1) and D(2) DA receptors in direct- and indirect-pathway spiny projection neurons. Although this hypothesis sparked a debate, the evidence that has accumulated since then clearly supports this model. Recent advances in the means of marking neural circuits with optical or molecular reporters have revealed a clear-cut dichotomy between these two cell types at the molecular, anatomical, and physiological levels. The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.