ReviewAnnual review of analytical chemistry (Palo Alto, Calif.)2011
Second-order nonlinear optical imaging of chiral crystals.
Review in Annual review of analytical chemistry (Palo Alto, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed.
- Chiral Metal Halides toward Circularly Polarized Photodetectors.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Application of a Rational Crystal Contact Engineering Strategy on a Poly(ethylene terephthalate)-Degrading Cutinase.Bioengineering (Basel, Switzerland) · 2025Article
- Comprehensive microcrystal electron diffraction sample preparation for cryo-EM.Nature protocols · 2025Review
- Reaching the potential of electron diffraction.Cell reports. Physical science · 2024Article
- The Interaction of 2D Materials With Circularly Polarized Light.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Article
- 20 years of crystal hits: progress and promise in ultrahigh-throughput crystallization screening.Acta crystallographica. Section D, Structural biology · 2023Article
- Sample Preparation for Time-Resolved Serial Crystallography: Practical Considerations.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Imaging Orientation of a Single Molecular Hierarchical Self-Assembled Sheet: The Combined Power of a Vibrational Sum Frequency Generation Microscopy and Neural Network.The journal of physical chemistry. B · 2022Article
- Elucidating the origin of chiroptical activity in chiral 2D perovskites through nano-confined growth.Nature communications · 2022Article
- An Overview of Microcrystal Electron Diffraction (MicroED).Annual review of biochemistry · 2021Review
- Integrated sample-handling and mounting system for fixed-target serial synchrotron crystallography.Acta crystallographica. Section D, Structural biology · 2021Article
- Structure Determination of Membrane Proteins Using X-Ray Crystallography.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Leaving the Limits of Linearity for Light Microscopy.The journal of physical chemistry. C, Nanomaterials and interfaces · 2020Article
- Rapid screening ofJournal of applied crystallography · 2020Article
- Construction of gateway-compatible baculovirus expression vectors for high-throughput protein expression and in vivo microcrystal screening.Scientific reports · 2020Article
- Optimization of crystallization of biological macromolecules using dialysis combined with temperature control.Journal of applied crystallography · 2020Article
- Surface-induced enantiomorphic crystallization of achiral fullerene derivatives in thin films.Chemical science · 2020Article
- Visualization of protein crystals by high-energy phase-contrast X-ray imaging.Acta crystallographica. Section D, Structural biology · 2019Article
- Characterization of Phase Transformations for Amorphous Solid Dispersions of a Weakly Basic Drug upon Dissolution in Biorelevant Media.Pharmaceutical research · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Second-order nonlinear optical imaging of chiral crystals (SONICC) is an emerging technique for crystal imaging and characterization. We provide a brief overview of the origin of second harmonic generation signals in SONICC and discuss recent studies using SONICC for biological applications. Given that they provide near-complete suppression of any background, SONICC images can be used to determine the presence or absence of protein crystals through both manual inspection and automated analysis. Because SONICC creates high-resolution images, nucleation and growth kinetics can also be observed. SONICC can detect metastable, homochiral crystalline forms of amino acids crystallizing from racemic solutions, which confirms Ostwald's rule of stages for crystal growth. SONICC's selectivity, based on order, and sensitivity, based on background suppression, make it a promising technique for numerous fields concerned with chiral crystal formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.