ArticleChemical research in toxicology2011
Profiling the reactive metabolites of xenobiotics using metabolomic technologies.
Article in Chemical research in toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
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- Investigation of Fenebrutinib Metabolism and Bioactivation Using MSMolecules (Basel, Switzerland) · 2023Article
- Profiling ofRSC advances · 2022Article
- Review
- Roles of Cofactors in Drug-Induced Liver Injury: Drug Metabolism and Beyond.Drug metabolism and disposition: the biological fate of chemicals · 2022Review
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice.Drug metabolism and disposition: the biological fate of chemicals · 2022Article
- Article
- In Vitro Metabolism of Donepezil in Liver Microsomes Using Non-Targeted Metabolomics.Pharmaceutics · 2021Article
- Approaches in metabolomics for regulatory toxicology applications.The Analyst · 2021Review
- Inhibitory Effects ofPharmaceutics · 2021Article
- Metabolic Activation of the Toxic Natural Products From Herbal and Dietary Supplements Leading to Toxicities.Frontiers in pharmacology · 2021Review
- An Untargeted Approach for Revealing Electrophilic Metabolites.ACS chemical biology · 2020Article
- Metabolic profiling of norepinephrine reuptake inhibitor atomoxetine.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2020Article
- Identification and characterization ofRSC advances · 2020Article
- Application of Metabolomics in the Study of Natural Products.Natural products and bioprospecting · 2018Article
- The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes.Frontiers in pharmacology · 2018Article
- Revisiting the Metabolism and Bioactivation of Ketoconazole in Human and Mouse Using Liquid Chromatography-Mass Spectrometry-Based Metabolomics.International journal of molecular sciences · 2017Article
- The Opportunities of Metabolomics in Drug Safety Evaluation.Current pharmacology reports · 2017Article
- Transgenic mice and metabolomics for study of hepatic xenobiotic metabolism and toxicity.Expert opinion on drug metabolism & toxicology · 2015Review
- Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver.The Journal of biological chemistry · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
A predominant pathway of xenobiotic-induced toxicity is initiated by bioactivation. Characterizing reactive intermediates will provide information on the structure of reactive species, thereby defining a potential bioactivation mechanism. Because most reactive metabolites are not stable, it is difficult to detect them directly. Reactive metabolites can form adducts with trapping reagents, such as glutathione, which makes the reactive metabolites detectable. However, it is challenging to "fish" these adducts out from a complex biological matrix, especially for adducts generated via uncommon metabolic pathways. In this regard, we developed a novel approach based upon metabolomic technologies to screen trapped reactive metabolites. The bioactivation of pulegone, acetaminophen, and clozapine were reexamined by using this metabolomic approach. In all these cases, a large number of trapped reactive metabolites were readily identified. These data indicate that this metabolomic approach is an efficient tool to profile xenobiotic bioactivation.
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Registered trials
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