ArticleJournal of proteome research2011
A quantitative proteomic approach to prion disease biomarker research: delving into the glycoproteome.
Article in Journal of proteome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
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- Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma.NPJ systems biology and applications · 2021Article
- Stable isotope dimethyl labelling for quantitative proteomics and beyond.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Review
- Detection of misfolded protein aggregates from a clinical perspective.Journal of clinical and translational research · 2016Review
- Quantitative proteomic analysis for high-throughput screening of differential glycoproteins in hepatocellular carcinoma serum.Cancer biology & medicine · 2015Article
- High-resolution enabled 12-plex DiLeu isobaric tags for quantitative proteomics.Analytical chemistry · 2015Article
- New insight into neurodegeneration: the role of proteomics.Molecular neurobiology · 2014Review
- Mass Spectrometry-based Proteomics and Peptidomics for Systems Biology and Biomarker Discovery.Frontiers in biology · 2012Article
- Neuropeptide analysis with liquid chromatography-capillary electrophoresis-mass spectrometric imaging.Journal of separation science · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Mass spectrometry (MS) -- based proteomic approaches have evolved as powerful tools for the discovery of biomarkers. However, the identification of potential protein biomarkers from biofluid samples is challenging because of the limited dynamic range of detection. Currently there is a lack of sensitive and reliable premortem diagnostic test for prion diseases. Here, we describe the use of a combined MS-based approach for biomarker discovery in prion diseases from mouse plasma samples. To overcome the limited dynamic range of detection and sample complexity of plasma samples, we used lectin affinity chromatography and multidimensional separations to enrich and isolate glycoproteins at low abundance. Relative quantitation of a panel of proteins was obtained by a combination of isotopic labeling and validated by spectral counting. Overall 708 proteins were identified, 53 of which showed more than 2-fold increase in concentration whereas 58 exhibited more than 2-fold decrease. A few of the potential candidate markers were previously associated with prion or other neurodegenerative diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.