ArticleEuropean journal of immunology2011
Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.
Article in European journal of immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Themis controls T cell activation, effector functions, and metabolism of peripheral CD8Life science alliance · 2023Article
- PRMT5 Is Required for T Cell Survival and Proliferation by Maintaining Cytokine Signaling.Frontiers in immunology · 2020Article
- Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses.Frontiers in immunology · 2019Review
- Diacylglycerol Kinase ζ Is a Target To Enhance NK Cell Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- TCR signaling by conventional CD4Immunity, inflammation and disease · 2016Article
- Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics.Molecular & cellular proteomics : MCP · 2015Article
- Regulatory T cells require TCR signaling for their suppressive function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Differential targeting of IL-2 and T cell receptor signaling pathways selectively expands regulatory T cells while inhibiting conventional T cells.Journal of autoimmunity · 2013Article
- Article
- Homeostatic division is not necessary for antigen-specific CD4+ memory T cell persistence.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Cutting edge: IL-2 signals determine the degree of TCR signaling necessary to support regulatory T cell proliferation in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Site-specific accumulation of recently activated CD4+ Foxp3+ regulatory T cells following adoptive transfer.European journal of immunology · 2012Article
- Oral ivermectin as an unexpected initiator of CreT2-mediated deletion in T cells.Nature immunology · 2012Article
- Understanding signal integration through targeted mutations of an adapter protein.FEBS letters · 2010Article
- The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The adaptor protein Src homology 2 domain-containing leukocyte-specific protein of 76 kDa (SLP-76) is central to the organization of intracellular signaling downstream of the T-cell receptor (TCR). Evaluation of its role in mature, primary T cells has been hampered by developmental defects that occur in the absence of WT SLP-76 protein in thymocytes. Here, we show that following tamoxifen-regulated conditional deletion of SLP-76, mature, antigen-inexperienced T cells maintain normal TCR surface expression but fail to transduce TCR-generated signals. Conditionally deficient T cells fail to proliferate in response to antigenic stimulation or a lymphopenic environment. Mice with induced deletion of SLP-76 are resistant to induction of the CD4+ T-cell-mediated autoimmune disease experimental autoimmune encephalomyelitis. Altogether, our findings demonstrate the critical role of SLP-76-mediated signaling in initiating T-cell-directed immune responses both in vitro and in vivo and highlight the ability to analyze signaling processes in mature T cells in the absence of developmental defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.