ArticleInternational journal of occupational medicine and environmental health2011
Occupational exposure to trichloroethylene and cancer risk for workers at the Paducah Gaseous Diffusion Plant.
Article in International journal of occupational medicine and environmental health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 21 citations in OpenAlex.
- The Nuclear Legacy in Appalachia.Journal of Appalachian health · 2020Article
- Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis.Molecular and clinical oncology · 2018Article
- Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.The Journal of pharmacology and experimental therapeutics · 2016Review
- Residential cancer cluster investigation nearby a Superfund Study Area with trichloroethylene contamination.Cancer causes & control : CCC · 2016Article
- Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.Pharmacology & therapeutics · 2014Review
Corrections and comments
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Authors and funding
27 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThe Paducah Gaseous Diffusion Plant (PGDP) became operational in 1952; it is located in the western part of Kentucky. We conducted a mortality study for adverse health effects that workers may have suffered while working at the plant, including exposures to chemicals. MATERIALS AND
methodsWe studied a cohort of 6820 workers at the PGDP for the period 1953 to 2003; there were a total of 1672 deaths to cohort members. Trichloroethylene (TCE) is a specific concern for this workforce; exposure to TCE occurred primarily in departments that clean the process equipment. The Life Table Analysis System (LTAS) program developed by NIOSH was used to calculate the standardized mortality ratios for the worker cohort and standardized rate ratio relative to exposure to TCE (the U.S. population is the referent for ageadjustment). LTAS calculated a significantly low overall SMR for these workers of 0.76 (95% CI: 0.72-0.79). A further review of three major cancers of interest to Kentucky produced significantly low SMR for trachea, bronchus, lung cancer (0.75, 95% CI: 0.72-0.79) and high SMR for Non-Hodgkin's lymphoma (NHL) (1.49, 95% CI: 1.02-2.10).
resultsNo significant SMR was observed for leukemia and no significant SRRs were observed for any disease. Both the leukemia and lung cancer results were examined and determined to reflect regional mortality patterns. However, the Non-Hodgkin's Lymphoma finding suggests a curious amplification when living cases are included with the mortality experience.
conclusionsFurther examination is recommended of this recurrent finding from all three U.S. Gaseous Diffusion plants.
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Registered trials
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