ArticleProtein & cell2011
An unexpected similarity between antibiotic-resistant NDM-1 and beta-lactamase II from Erythrobacter litoralis.
Article in Protein & cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Predatory myxobacteria lay at the cross-roads of metallo-β-lactamase evolution.Communications biology · 2026Article
- First characterization of four repeat regions with theiScience · 2025Article
- Strategies to Name Metallo-β-Lactamases and Number Their Amino Acid Residues.Antibiotics (Basel, Switzerland) · 2023Review
- Coexistence ofFrontiers in microbiology · 2023Article
- Co-Existence of KPC-2, LAP-2, and CTX-M-65 in an ST1469 Multidrug-ResistantInfection and drug resistance · 2022Article
- OXA-900, a Novel OXA Sub-Family Carbapenemase Identified inMicroorganisms · 2021Article
- Environmental hotspots for antibiotic resistance genes.MicrobiologyOpen · 2021Review
- Article
- Active-Site Conformational Fluctuations Promote the Enzymatic Activity of NDM-1.Antimicrobial agents and chemotherapy · 2018Article
- Biochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium Erythrobacter litoralis HTCC 2594.Scientific reports · 2018Article
- Characterization of a novel metallo-β-lactamases fold hydrolase from Pelagibacterium halotolerans, a marine halotolerant bacterium isolated from East China Sea.Extremophiles : life under extreme conditions · 2016Article
- Spectroscopic and mechanistic studies of heterodimetallic forms of metallo-β-lactamase NDM-1.Journal of the American Chemical Society · 2014Article
- The culturable soil antibiotic resistome: a community of multi-drug resistant bacteria.PloS one · 2013Article
- Metallo-β-lactamase 1--why blame New Delhi & India?The Indian journal of medical research · 2013Article
- Investigating antibiotic resistance in non-clinical environments.Frontiers in microbiology · 2013Article
- Identification and characterization of a novel incompatibility group X3 plasmid carrying bla NDM-1 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China.Emerging microbes & infections · 2012Article
- An octamer of enolase from Streptococcus suis.Protein & cell · 2012Article
- SMB-1, a novel subclass B3 metallo-beta-lactamase, associated with ISCR1 and a class 1 integron, from a carbapenem-resistant Serratia marcescens clinical isolate.Antimicrobial agents and chemotherapy · 2011Article
- Article
- Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase.PloS one · 2011Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NDM-1 (New Delhi metallo-beta-lactamase) gene encodes a metallo-beta-lactamase (MBL) with high carbapenemase activity, which makes the host bacterial strain easily dispatch the last-resort antibiotics known as carbapenems and cause global concern. Here we present the bioinformatics data showing an unexpected similarity between NDM-1 and beta-lactamase II from Erythrobacter litoralis, a marine microbial isolate. We have further expressed these two mature proteins in E. coli cells, both of which present as a monomer with a molecular mass of 25 kDa. Antimicrobial susceptibility assay reveals that they share similar substrate specificities and are sensitive to aztreonam and tigecycline. The conformational change accompanied with the zinc binding visualized by nuclear magnetic resonance, Zn(2+)-bound NDM-1, adopts at least some stable tertiary structure in contrast to the metal-free protein. Our work implies a close evolutionary relationship between antibiotic resistance genes in environmental reservoir and in the clinic, challenging the antimicrobial resistance monitoring.
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