Evidence map›Paper›PMID 21468892›Full record

ReviewProtein & cell2011

Structure and function of WD40 domain proteins.

Chao Xu, Jinrong Min

Abstract readReview
In one paragraph

Review in Protein & cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 375 papers.

0numbers the graph read from it
0cells of the map it votes in
375citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

375 citing papers in PubMed.

  1. Article
  2. Oral Actinobacteria sense and defend against parasitic epibionts.bioRxiv : the preprint server for biology · 2026
    Article
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  6. Review
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  11. Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  13. Article
  14. Article
  15. Article
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  17. Review
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  19. Review
  20. Article

315 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chao XuStructural Genomics Consortium, University of Toronto, 101 College St., Toronto, Ontario, Canada.
Jinrong Min

Funding

Canadian Institutes of Health ResearchWellcome Trust
6 · The paper itself

Abstract

The WD40 domain exhibits a β-propeller architecture, often comprising seven blades. The WD40 domain is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes. In this review, we will discuss the identification, definition and architecture of the WD40 domains. WD40 domain proteins are involved in a large variety of cellular processes, in which WD40 domains function as a protein-protein or protein-DNA interaction platform. WD40 domain mediates molecular recognition events mainly through the smaller top surface, but also through the bottom surface and sides. So far, no WD40 domain has been found to display enzymatic activity. We will also discuss the different binding modes exhibited by the large versatile family of WD40 domain proteins. In the last part of this review, we will discuss how post-translational modifications are recognized by WD40 domain proteins.

Indexed as

Repetitive Sequences, Amino AcidAmino Acid MotifsAmino Acid SequenceAnimalsHumansMolecular Sequence DataProtein Processing, Post-TranslationalProteinsProtein Structure, TertiaryProteins

Identifiers

PMID21468892
PMCPMC4875305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.