SynthesisJournal of cancer research and clinical oncology2011
IL-8-251A>T polymorphism is associated with breast cancer risk: a meta-analysis.
Synthesis in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Ethnic background and genetic variation in the evaluation of cancer risk: a systematic review.PloS one · 2014Pooled it
- DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.Molecular biology reports · 2012Pooled it
- Identification of immune-related mechanisms of cetuximab induced skin toxicity in colorectal cancer patients.PloS one · 2022Article
- [Association between interleukin-8 rs4073 polymorphisms and susceptibility to neonatal sepsis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Association of IL-8 gene promoter -251 A/T and IL-18 gene promoter -137 G/C polymorphisms with head and neck cancer risk: a comprehensive meta-analysis.Cancer management and research · 2018Review
- IL-8 -251A/T and +781C/T polymorphisms were associated with risk of breast cancer in a Chinese population.International journal of clinical and experimental pathology · 2017Article
- The CXCL8-CXCR1/2 pathways in cancer.Cytokine & growth factor reviews · 2016Review
- Association between interleukin 8-251 T/A and +781 C/T polymorphisms and glioma risk.Diagnostic pathology · 2015Article
- Positive association between Interleukin-8 -251A > T polymorphism and susceptibility to gastric carcinogenesis: a meta-analysis.Cancer cell international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIL-8-251A>T polymorphisms have been reported to influence the risk for breast cancer in many studies; however, the results still remain controversial and ambiguous. The aim of this study was to determine more precise estimations for the relationship between IL-8-251A>T polymorphisms and the risk for breast cancer.
methodsElectronic searches for all publications were conducted on association between this variant and breast cancer in several databases through November 2010. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the strength of the association. Six studies were identified, including 1,880 breast cancer patients and 2,013 controls.
resultsOverall, no significant associations between IL-8-251A>T polymorphism and breast cancer (codominant model: TA vs. AA OR = 1.075, 95%CI = 0.864-1.337; TT vs. AA, OR = 0.900, 95%CI = 0.598-1.354; dominant model: OR = 1.011, 95%CI = 0.783-1.304; and recessive model: OR = 0.854, 95%CI = 0.623-1.171). In the subgroup analysis by ethnicity, significantly decreased risk was found for Africans (TT vs. AA OR = 0.541; 95%CI = 0.396-0.741; dominant model: OR = 0.737, 95%CI = 0.570-0.953; recessive model: OR = 0.594; 95%CI = 0.459-0.768). In the stratified analysis by control sources, significant association was observed in population-based studies (recessive model: OR = 0.692; 95%CI = 0.566-0.861).
conclusionsThis meta-analysis suggests the IL-8-251A/T polymorphism is associated with breast cancer risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.