ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2011
Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global burden ofJournal of global health · 2019Pooled it
- The emergence of Clostridium difficile infection in Asia: A systematic review and meta-analysis of incidence and impact.PloS one · 2017Pooled it
- A Colombian strain ofVirulence · 2025Article
- Increase ofMicrobiology spectrum · 2025Article
- Best Practices in the Management ofTropical medicine and infectious disease · 2024Review
- Genomic study of EuropeanMicrobial genomics · 2024Article
- Insights into the Evolving Epidemiology ofAntibiotics (Basel, Switzerland) · 2023Review
- Systems biology approach to functionally assess theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Antimicrobial Susceptibilities of Clostridium difficile Isolates from 12 Asia-Pacific Countries in 2014 and 2015.Antimicrobial agents and chemotherapy · 2020Article
- Biological characteristics associated with virulence inEmerging microbes & infections · 2020Article
- Two-year analysis of Clostridium difficile ribotypes associated with increased severity.The Journal of hospital infection · 2019Article
- Clostridium difficile-associated Diarrhea in Developing Countries: A Systematic Review and Meta-Analysis.Infectious diseases and therapy · 2019Article
- Review
- Evidence of transmission of Clostridium difficile in asymptomatic patients following admission screening in a tertiary care hospital.PloS one · 2019Article
- Review
- Article
- Surveillance of antibiotic resistance among common Clostridium difficile ribotypes in Hong Kong.Scientific reports · 2017Article
- Disease Burden of Clostridium difficile Infections in Adults, Hong Kong, China, 2006-2014.Emerging infectious diseases · 2017Observational
- Clostridium difficile Infection.Microbiology spectrum · 2016Review
- Clinical Characteristics and Treatment Outcomes of Clostridium difficile Infections by PCR Ribotype 017 and 018 Strains.PloS one · 2016Article
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Authors and funding
12 authors.
Funding
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Abstract
We identified a predominant clone of Clostridium difficile PCR ribotype 002, which was associated with an increased sporulation frequency. In 2009, 3,528 stool samples from 2,440 patients were tested for toxigenic C. difficile in a healthcare region in Hong Kong. A total of 345 toxigenic strains from 307 (13.3%) patients were found. Ribotype 002 was the predominant ribotype, which constituted 35 samples from 29 (9.4%) patients. The mean sporulation frequency of ribotype 002 was 20.2%, which was significantly higher than that of the 56 randomly selected ribotypes other than 002 as concurrent controls (3.7%, p < 0.001). Patients carrying toxigenic ribotype 002 were more frequently admitted from an elderly home (p = 0.01) and received more β-lactam antibiotics in the preceding 3 months compared with the controls (p = 0.04) . The identification of toxigenic ribotype 002 in 2009 was temporally related to a significant increase in both the incidence of toxigenic C. difficile from 0.53 to 0.95 per 1,000 admissions (p < 0.001) and the rate of positive detection from 4.17% to 6.28% (p < 0.001) between period 1 (2004-2008) and period 2 (2009). This finding should alert both the physician and the infection control team to the establishment of and possible outbreaks by ribotype 002 in our hospitals, as in the case of ribotype 027.
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