ArticleInternational journal of nanomedicine2011
Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid.
Article in International journal of nanomedicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
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- A review of drug delivery systems based on nanotechnology and green chemistry: green nanomedicine.International journal of nanomedicine · 2017Review
- Increased cellular uptake of lauryl gallate loaded in superparamagnetic poly(methyl methacrylate) nanoparticles due to surface modification with folic acid.Journal of materials science. Materials in medicine · 2016Article
- Apoptosis selectively induced in BEL-7402 cells by folic acid-modified magnetic nanoparticles combined with 100 Hz magnetic field.International journal of nanomedicine · 2014Article
- Immune response to nanomaterials: implications for medicine and literature review.Current allergy and asthma reports · 2013Review
- Phagocytes mediate targeting of iron oxide nanoparticles to tumors for cancer therapy.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Cytotoxicity evaluation of carbon-encapsulated iron nanoparticles in melanoma cells and dermal fibroblasts.Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology · 2013Article
- Expression and preliminary functional analysis of Siglec-F on mouse macrophages.Journal of Zhejiang University. Science. B · 2012Article
- RGDS-functionalized polyethylene glycol hydrogel-coated magnetic iron oxide nanoparticles enhance specific intracellular uptake by HeLa cells.International journal of nanomedicine · 2012Article
- Use of biotin targeted methotrexate-human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy.International journal of nanomedicine · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnetic nanoparticles show great promise for use as tools in a wide variety of biomedical applications. The purpose of this study was to investigate the potential effects of methacrylamido-folic acid (Ma-Fol)-modified magnetic nanoparticles on 5RP7 (H-ras-transformed rat embryonic fibroblasts) and NIH/3T3 (normal mouse embryonic fibroblasts).
methodsThe cytotoxicity and viability of 5RP7 and NIH/3T3 cells were detected. The percentage of cells undergoing apoptosis was analyzed by flow cytometry using Annexin V-fluorescein isothiocyanate staining. Nanoparticle internalization into 5RP7 and NIH/3T3 cells was visualized by transmission electron microscopy.
conclusionIn this study, folic acid coupled to the surface of iron oxide for selective binding to cancer cells and immobilized the surfaces of magnetic nanoparticles. This complex improves cell internalization and targeting of cancer cells. We detected increased apoptosis using flow cytometry and transmission electron microscopy.
resultsFolic acid modification of magnetic nanoparticles could be used to facilitate uptake to specific cancer cells for cancer therapy and diagnosis. Our results showed that the uptake of folic-acid modified nanoparticles by 5RP7 cancer cells was also much higher than that of 3T3 cells. This modification can be used for successful targeting of cancer cells expressing the folate receptor.
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