ArticlePloS one2011
Three-dimensional traction force microscopy: a new tool for quantifying cell-matrix interactions.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.
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Who cites it
118 citing papers in PubMed.
- Cell-Extracellular Matrix Feedback Results in Spontaneous Cell Polarization and Heterogeneous Remodeling in 3D Isotropic and Aligned Discrete-Fiber Models of Cell-Mediated Remodeling.Cellular and molecular bioengineering · 2026Article
- Double Sided Traction Force Microscopy: A Method to Confine Cells for Physiologically Relevant Force Measurements.Cytoskeleton (Hoboken, N.J.) · 2026Article
- napariTFM: An open-source tool for traction force microscopy and monolayer stress microscopy.PLoS computational biology · 2026Article
- 3D force microscopy for volumetric quantification of ultrasound-induced loading: applications for bone repair.Biomechanics and modeling in mechanobiology · 2025Article
- Unlocking the therapeutic potential of cellular mechanobiology.Science advances · 2025Review
- Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Three-dimensional traction technology and its application in mechanomedicine.Mechanobiology in medicine · 2025Review
- Aligned Collagen Fibers Drive Distinct Traction Force Signatures to Regulate Contact Guidance.ACS nano · 2025Article
- Quantifying hygroscopic deformation in lignocellulosic tissues: a digital volume correlation tool comparison.Frontiers in plant science · 2025Article
- 3D Micropatterned Traction Force Microscopy: A Technique to Control 3D Cell Shape While Measuring Cell-Substrate Force Transmission.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- 3D Traction Force Microscopy in Biological Gels: From Single Cells to Multicellular Spheroids.Annual review of biomedical engineering · 2024Review
- Tracking single hiPSC-derived cardiomyocyte contractile function using CONTRAX an efficient pipeline for traction force measurement.Nature communications · 2024Article
- Cellular Traction Force Holds the Potential as a Drug Testing Readout for In Vitro Cancer Metastasis.Cellular and molecular bioengineering · 2024Article
- The Plasma Membrane and Mechanoregulation in Cells.ACS omega · 2024Review
- Comparative analysis of traction forces in normal and glaucomatous trabecular meshwork cells within a 3D, active fluid-structure interaction culture environment.Acta biomaterialia · 2024Article
- Dynamic traction force in trabecular meshwork cells: A 2D culture model for normal and glaucomatous states.Acta biomaterialia · 2024Article
- High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy.Communications biology · 2024Article
- Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility.Matrix biology : journal of the International Society for Matrix Biology · 2023Article
- Adhesion tunes speed and persistence by coordinating protrusions and extracellular matrix remodeling.Developmental cell · 2023Article
- Fungus-derived protein particles as cell-adhesive matrices for cell-cultivated food.NPJ science of food · 2023Article
58 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The interactions between biochemical processes and mechanical signaling play important roles during various cellular processes such as wound healing, embryogenesis, metastasis, and cell migration. While traditional traction force measurements have provided quantitative information about cell matrix interactions in two dimensions, recent studies have shown significant differences in the behavior and morphology of cells when placed in three-dimensional environments. Hence new quantitative experimental techniques are needed to accurately determine cell traction forces in three dimensions. Recently, two approaches both based on laser scanning confocal microscopy have emerged to address this need. This study highlights the details, implementation and advantages of such a three-dimensional imaging methodology with the capability to compute cellular traction forces dynamically during cell migration and locomotion. An application of this newly developed three-dimensional traction force microscopy (3D TFM) technique to single cell migration studies of 3T3 fibroblasts is presented to show that this methodology offers a new quantitative vantage point to investigate the three-dimensional nature of cell-ECM interactions.
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