ArticleTranscription2011
Heterochromatin protein 1a is required for an open chromatin structure.
Article in Transcription, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Functions of HP1 proteins in transcriptional regulation.Epigenetics & chromatin · 2022Review
- Liquid-like interactions in heterochromatin: Implications for mechanism and regulation.Current opinion in cell biology · 2020Review
- Molecular effects of dADD1 misexpression in chromatin organization and transcription.BMC molecular and cell biology · 2020Article
- Molecular and genetic organization of bands and interbands in the dot chromosome of Drosophila melanogaster.Chromosoma · 2019Article
- TheGenetics · 2018Article
- Article
- The Differences Between Cis- and Trans-Gene Inactivation Caused by Heterochromatin in Drosophila.Genetics · 2016Article
- A balancing act: heterochromatin protein 1a and the Polycomb group coordinate their levels to silence chromatin in Drosophila.Epigenetics & chromatin · 2015Article
- HP1a: a structural chromosomal protein regulating transcription.Trends in genetics : TIG · 2014Review
- HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster.Nucleic acids research · 2013Article
- Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain.PLoS genetics · 2012Article
- HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster.PLoS genetics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila melanogaster fourth chromosome contains interspersed domains of active and repressive chromatin. We investigated a stock harboring a silenced transgene inserted into Dyrk3 and near Caps-two expressed genes on chromosome four. In an HP1a-deficient background, transgene expression was activated while, paradoxically, expression of Dyrk3 and Caps was reduced. We found that the promoters of Dyrk3 and Caps contained DNase I hypersensitive sites but also possessed methylated histone H3 and HP1a, marks of repressive chromatin. In HP1a-deficient flies, the Dyrk3 and Caps promoters displayed diminished accessibility to nuclease digestion, revealing a surprising role for HP1a in opening chromatin.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.