ReviewNature reviews. Urology2011
Hydrogen sulfide and erectile function: a novel therapeutic target.
Review in Nature reviews. Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- Gas signaling molecule: a new research focus in the treatment of erectile dysfunction.Medical gas research · 2027Review
- Systemic sodium hydrosulfide (NaHS) administration mitigates reperfusion injury in an experimental model of ischemic priapism.World journal of urology · 2026Article
- Hydrogen sulfide and its role in female reproduction.Frontiers in veterinary science · 2024Review
- Modulation of Human Hydrogen Sulfide Metabolism by Micronutrients, Preliminary Data.Nutrition and metabolic insights · 2022Article
- Molecular pathogenesis and treatment of cavernous nerve injury-induced erectile dysfunction: A narrative review.Frontiers in physiology · 2022Review
- Gut microbiota supports male reproductionFrontiers in microbiology · 2022Review
- Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis.Oxidative medicine and cellular longevity · 2021Review
- Alleviation of impaired reactivity in the corpus cavernosum of STZ-diabetic rats by slow-release HInternational journal of impotence research · 2019Article
- Urothelium muscarinic activation phosphorylates CBS(Ser227) via cGMP/PKG pathway causing human bladder relaxation through H2S production.Scientific reports · 2016Article
- Dietary flavonoid intake and incidence of erectile dysfunction.The American journal of clinical nutrition · 2016Observational
- Gas what: NO is not the only answer to sexual function.British journal of pharmacology · 2015Review
- Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium.PloS one · 2015Article
- H2S relaxes isolated human airway smooth muscle cells via the sarcolemmal K(ATP) channel.Biochemical and biophysical research communications · 2014Article
- Hydrogen sulfide in biochemistry and medicine.Antioxidants & redox signaling · 2012Review
- New insights into hypertension-associated erectile dysfunction.Current opinion in nephrology and hypertension · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen sulfide (H(2)S) is a gaseous transmitter involved in the control of vascular homeostasis. H(2)S is formed endogenously from L-cysteine or L-methionine by two enzymes, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), and normally circulates in blood. Studies from the past few years have demonstrated the involvement of H(2)S in erectile mechanisms in animal and human tissues. Exogenous H(2)S relaxes human and animal tissues in vitro and increases intracavernous pressure in experimental animal models. Electrical field stimulation studies on animal and human tissues have demonstrated that endogenous H(2)S is involved in the physiological control of penile tone. In humans, both CBS and CSE are widely expressed on trabecular muscle, implying that the smooth muscle component is the major source of H(2)S. Thus, the L-cysteine-H(2)S pathway may represent a promising target for development of new therapeutics for erectile dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.