Evidence map›Paper›PMID 21467936›Full record

ReviewCurrent opinion in organ transplantation2011

Posttransplant lymphoproliferative disease following liver transplantation.

Kala Y Kamdar, Cliona M Rooney, Helen E Heslop

Abstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 100 citations in OpenAlex.

  1. Machine Learning-Based Evaluation of Combined EBV and CMV Serostatus as Predictors of Post-Transplant Lymphoproliferative Disorder.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. The role of natural killer T cells in liver transplantation.Frontiers in cell and developmental biology · 2023
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Infectious Complications After Liver Transplantation.Gastroenterology & hepatology · 2015
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Kala Y KamdarDepartment of Pediatrics, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, Texas, USA. kykamdar@txccc.org
Cliona M Rooney
Helen E Heslop
Baylor College of Medicine · USHouston Methodist · USTexas Children's Hospital · US

Funding

Tissue ResourceP50CA126752 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Andrea Nicole Marcogliese · 2007 to 2026
$51.4M
VECTOR PRODUCTIONP01CA094237 · NCI · BAYLOR COLLEGE OF MEDICINE · PI HESLOP, HELEN E, ROONEY, CLIONA M. · 2002 to 2017
$27.8M
Validation of Suicide Strategies for Cellular TherapyU54HL081007 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI BRENNER, MALCOLM K. · 2005 to 2009
$10.2M
NCI NIH HHS P01 CA094237NCI NIH HHS P01 CA94237NCI NIH HHS P50 CA126752NCI NIH HHS P50CA126752NHLBI NIH HHS HHSN268201000007CNHLBI NIH HHS U54 HL081007NHLBI NIH HHS U54HL081007
6 · The paper itself

Abstract

purpose of reviewDespite contemporary immunosuppressive regimens, posttransplant lymphoproliferative disease (PTLD) remains a major complication after liver transplantation. This review highlights advances in the understanding of the pathophysiology, diagnosis, and management of PTLD in liver transplant recipients. RECENT

findingsThe spectrum of PTLD after liver transplant ranges from polymorphic lymphoproliferation to high-grade monoclonal lymphoma and is usually related to outgrowth of lymphocytes infected with Epstein-Barr virus (EBV). Risk factors for PTLD include EBV-seronegativity of the recipient, young age, intensity of immunosuppression, and the first year posttransplant. Measurement of EBV load by quantitative polymerase chain reaction assays is an important aid in the surveillance and diagnosis of PTLD although the specificity for PTLD is only about 50% (specificity for EBV is ∼100%). In patients diagnosed with PTLD, management options include reduction of immunosuppression, rituximab, combination chemotherapy, and adoptive immunotherapy. Outcomes have improved because rituximab has been incorporated into treatment regimens, and immunotherapy approaches show promise. SUMMARY: PTLD is a significant complication after liver transplantation, particularly in children. Advances in early detection approaches have aided in the diagnosis and management of PTLD, but further research to identify better predictive biomarkers is needed to improve risk-based treatment strategies.

Indexed as

Age FactorsEarly DiagnosisEpstein-Barr Virus InfectionsHumansImmunosuppressive AgentsLiver TransplantationLymphoproliferative DisordersPredictive Value of TestsRisk AssessmentRisk FactorsTreatment OutcomeImmunosuppressive Agents

Identifiers

PMID21467936
PMCPMC3167800
OpenAlexW1968923103

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.