ArticleThe Plant cell2011
MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.
Article in The Plant cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers.
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123 citing papers in PubMed, 273 citations in OpenAlex.
- Mechanism Underlying the Color Differences in Apples Based on Metabolomic and Transcriptomic Analyses.International journal of molecular sciences · 2026Article
- Completing the acylation landscape in plants: GDSL enzymes join the BAHD and SCPL acyltransferase families.Journal of experimental botany · 2026Review
- Time-Resolved Secondary Metabolite Profiling of Seeded and Seedless Ougan at Commercial Harvest Maturity.Current issues in molecular biology · 2026Article
- Identification of a unique tea germplasm exhibiting hyperaccumulation of trans-catechins and its molecular regulatory mechanism.Food chemistry. Molecular sciences · 2026Article
- Trait Association for Flowering Time in Lentil from Global Multi-Environment Data Using GWAS and Machine Learning.Plants (Basel, Switzerland) · 2026Article
- The vacuolar transporters MaMATE11 and MaMATE14 affect blue flower coloration in grape hyacinth (Horticulture research · 2026Article
- A Multidrug and Toxic Compound Extrusion Transporter, RgMATE6, Facilitates Vacuolar Transport of Acteoside inPlants (Basel, Switzerland) · 2025Article
- Transcriptomic Insights into Anthocyanin Biosynthesis inInternational journal of molecular sciences · 2025Article
- Article
- A novel function for the transcription factor sensitive to proton rhizotoxicity1 in promoting anthocyanin accumulation in strawberry.Plant biotechnology journal · 2025Article
- The G311E Mutant Gene of MATE Family Protein DTX6 Confers Diquat and Paraquat Resistance in Rice Without Yield or Nutritional Penalties.International journal of molecular sciences · 2025Article
- PdMATE16 and PdMATE35 are essential for the accumulation of multiple flavonoids in tree peonies.Frontiers in plant science · 2025Article
- Transportation engineering for enhanced production of plant natural products in microbial cell factories.Synthetic and systems biotechnology · 2024Review
- Differentially Expressed Genes Related to Isoflavone Biosynthesis in a Soybean Mutant Revealed by a Comparative Transcriptomic Analysis.Plants (Basel, Switzerland) · 2024Article
- Biosynthesis and metabolic engineering of isoflavonoids in model plants and crops: a review.Frontiers in plant science · 2024Review
- Broccoli (Frontiers in pharmacology · 2024Article
- Phenylpropanoid Content of Chickpea Seed Coats in Relation to Seed Dormancy.Plants (Basel, Switzerland) · 2023Article
- Vaccinium as a comparative system for understanding of complex flavonoid accumulation profiles and regulation in fruit.Plant physiology · 2023Article
- Flavonoids: a review on biosynthesis and transportation mechanism in plants.Functional & integrative genomics · 2023Review
- Deciphering the Genetic Architecture of Color Variation in Whole Grain Rice by Genome-Wide Association.Plants (Basel, Switzerland) · 2023Article
63 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of flavonoids, such as anthocyanins, proanthocyanidins, and isoflavones, are stored in the central vacuole, but the molecular basis of flavonoid transport is still poorly understood. Here, we report the functional characterization of a multidrug and toxin extrusion transporter (MATE2), from Medicago truncatula. MATE 2 is expressed primarily in leaves and flowers. Despite its high similarity to the epicatechin 3'-O-glucoside transporter MATE1, MATE2 cannot efficiently transport proanthocyanidin precursors. In contrast, MATE2 shows higher transport capacity for anthocyanins and lower efficiency for other flavonoid glycosides. Three malonyltransferases that are coexpressed with MATE2 were identified. The malonylated flavonoid glucosides generated by these malonyltransferases are more efficiently taken up into MATE2-containing membrane vesicles than are the parent glycosides. Malonylation increases both the affinity and transport efficiency of flavonoid glucosides for uptake by MATE2. Genetic loss of MATE2 function leads to the disappearance of leaf anthocyanin pigmentation and pale flower color as a result of drastic decreases in the levels of various flavonoids. However, some flavonoid glycoside malonates accumulate to higher levels in MATE2 knockouts than in wild-type controls. Deletion of MATE2 increases seed proanthocyanidin biosynthesis, presumably via redirection of metabolic flux from anthocyanin storage.
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