ArticleHuman reproduction (Oxford, England)2011
Trisomic pregnancy and elevated FSH: implications for the oocyte pool hypothesis.
Article in Human reproduction (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 45 citations in OpenAlex.
- Antimüllerian hormone and pregnancy loss from the Effects of Aspirin in Gestation and Reproduction trial.Fertility and sterility · 2016Trial
- Ovarian reserve testing: assessing oocyte quantity and quality.Journal of assisted reproduction and genetics · 2026Review
- Relationship between anti-Müllerian hormone concentration in the peripheral blood of women and aneuploid pregnancy.BMC pregnancy and childbirth · 2026Article
- A New Hypothesis on the Etiology of Down Syndrome: The Role of Anti-Zona Pellucida Antibodies as an Age-Independent Factor.International journal of molecular sciences · 2026Article
- Basal FSH values are positively associated with aneuploidy incidence in pre-advanced maternal age (AMA) but not in AMA patients.Journal of assisted reproduction and genetics · 2024Article
- Follicular fluid steroid and gonadotropic hormone levels and mitochondrial function from exosomes predict embryonic development.Frontiers in endocrinology · 2022Article
- The Incidence of Mosaicism for Individual Chromosome in Human Blastocysts Is Correlated With Chromosome Length.Frontiers in genetics · 2020Article
- Article
- Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age.Menopause (New York, N.Y.) · 2014Article
- The association between the oocyte pool and aneuploidy: a comparative study of the reproductive potential of young and aged mice.Journal of assisted reproduction and genetics · 2014Article
- Serum markers of ovarian reserve and ovarian histology in adult mice treated with cyclophosphamide in pre-pubertal age.Journal of assisted reproduction and genetics · 2013Article
- Article
- Follicular fluid protein content (FSH, LH, PG4, E2 and AMH) and polar body aneuploidy.Journal of assisted reproduction and genetics · 2012Article
- Trisomic pregnancy and intermediate CGG repeat length at the FMR1 locus.Human reproduction (Oxford, England) · 2012Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundSome studies, but not all, support the hypothesis that trisomy frequency is related to the size of the oocyte pool, with the risk increased for women with fewer oocytes (older ovarian age). We tested this hypothesis by comparing hormonal indicators of ovarian age among women who had trisomic pregnancy losses with indicators among women with non-trisomic losses or chromosomally normal births. The three primary indicators of advanced ovarian age were low level of anti-Müllerian hormone (AMH), high level of follicle-stimulating hormone (FSH) and low level of inhibin B.
methodsThe analysis drew on data from two hospital-based case-control studies. Data were analyzed separately and the evidence from the two sites was combined. We compared 159 women with trisomic pregnancy losses to three comparison groups: 60 women with other chromosomally abnormal losses, 79 women with chromosomally normal losses and 344 women with live births (LBs) age-matched to women with losses. We analyzed the hormone measures as continuous and as categorical variables. All analyses adjust for age in single years, day of blood draw, interval in storage and site.
resultsAMH and inhibin B did not differ between women with trisomic losses and any of the three comparison groups. Mean ln(FSH) was 0.137 units (95% confidence interval (CI): 0.055, 0.219) higher for trisomy cases compared with LB controls; it was also higher, though not significantly so, for trisomy cases compared with women with other chromosomally abnormal losses or chromosomally normal losses. The adjusted odds ratio in relation to high FSH (≥ 10 mIU/ml) was significantly increased for trisomy cases versus LB controls (adjusted odds ratio (OR): 3.8, 95% CI: 1.6, 8.9).
conclusionsThe association of trisomy with elevated FSH is compatible with the oocyte pool hypothesis, whereas the absence of an association with AMH is not. Alternative interpretations are considered, including the possibility that elevated FSH may disrupt meiotic processes or allow recruitment of abnormal follicles.
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